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Greater scientific understanding of cancer biology, the multistage process of carcinogenesis and tumour responses to conventional and targeted therapeutics have led to the development of combination therapies, for example, chemotherapy with immunotherapy, to achieve long-lasting efficacy and to target metastasis, which is currently the main cause of mortality in many types of cancer (Qin et al., 2020; Schirrmacher, 2019; Wu & Waxman, 2018; Yu et al., 2019). APPROACHES TO IMPROVE OUTCOMES OF EXISTING CANCER TREATMENTS The importance of precision medicine has been incorporated into developing cancer treatments as well as new strategies for decreasing the toxicity of chemotherapeutics and improving therapy outcomes. This article is part of a themed issue on New avenues in cancer prevention and treatment (BJP 75th Anniversary). Moreover, when applied in already developed cancers, nutritional interventions may stop or attenuate cancer progression by targeting cancer hallmarks, such as metastasis (Khadge et al., 2018; Sleeman, 2018). [Extracted from the article]

B Method/Summary of work b : We developed an NBA pipeline that (1) generates patient-specific disease networks by integrating and mapping multifaceted datasets (that include differentially expressed genes from patient's transcriptomic data, the deregulated transcription factors, disease-specific genes from GWAS studies and drug targets of interest) on to the large-scale protein-protein interaction network, (2) identifies key molecules and pathways in the patient-specific disease network and (3) scores each identified potential drug target based on the network connectivity score (that reflects signal propagation) and expression level. J Neurosci; 30: 573 - 582. https://doi.org/10.1523/JNEUROSCI.3295-09.2010 Oral Communications, Tuesday 7th September Oral Communications - Cardiovascular & Respiratory B OC001 b B The effects of allopurinol treatment in early period of monocrotaline-induced rat pulmonary hypertension model b Gokcen Telli SP 1 sp , Inci Kazkayasi SP 1 sp , E. Inci Ergonul SP 2 sp and Serdar Uma SP 1 sp SP 1 sp I Department of Pharmacology, Hacettepe University Faculty of Pharmacy; i SP 2 sp I Republic of Turkey Ministry of Health i B Introduction/Background & aims b : Along with the greater understanding of the pathogenesis of pulmonary hypertension (PH), one of the new treatment approaches is to evaluate the effectiveness of drugs used in diseases with pathologies similar to that of PH [1]. This study investigates the effect of this drug on cell death and proliferative signalling pathways in AML cells in vitro. [Extracted from the article]