1. Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet
- Author
-
Ronda, Onne A.H.O., Van De Heijning, Bert J.M., De Bruin, Alain, Jurdzinski, Angelika, Kuipers, Folkert, Verkade, Henkjan J., Sub General Pharmacology, dPB RMSC, LS Pathobiologie, Sub General Pharmacology, dPB RMSC, LS Pathobiologie, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Lifestyle Medicine (LM)
- Subjects
Male ,0301 basic medicine ,Medicine (miscellaneous) ,Adipose tissue ,Infant nutrition ,Mice ,chemistry.chemical_compound ,0302 clinical medicine ,Pyruvic Acid ,ABSORPTION ,Homeostasis ,BREAST-MILK ,Globules of fat ,Phospholipids ,Dietary lipids ,Nutrition and Dietetics ,Lipid structure ,CHOLESTEROL ,DROPLETS ,Animal models ,Phenotype ,Adipose Tissue ,ACID ,Body Composition ,Female ,Obesity prevention ,Life Sciences & Biomedicine ,medicine.medical_specialty ,Phospholipid ,030209 endocrinology & metabolism ,Breast milk ,Diet, High-Fat ,03 medical and health sciences ,Milk fat globule membrane ,Internal medicine ,Metabolic programming ,medicine ,Animals ,Lipolysis ,Obesity ,Glycoproteins ,ACCUMULATION ,Food, Formulated ,FORMULA ,Science & Technology ,030109 nutrition & dietetics ,Nutrition & Dietetics ,Cholesterol ,Gene Expression Profiling ,Body Weight ,Lipid Droplets ,medicine.disease ,Animal Feed ,Dietary Fats ,Diet ,Mice, Inbred C57BL ,Glucose ,SIZE ,Endocrinology ,chemistry ,TISSUE ,Glycolipids ,Breast feeding ,LIPOLYSIS - Abstract
Breast-feeding is associated with a lower risk of developing obesity during childhood and adulthood compared with feeding infant milk formula (IMF). Previous studies have shown that an experimental IMF (eIMF; comprising Nuturis®) programmed mouse pups for a lower body weight and fat mass gain in adulthood when challenged with a high-fat diet (HFD) compared with a control IMF (cIMF). Nuturis has a lipid composition and structure more similar to breast milk. Here, the long-term effects were tested of a similar eIMF, but with an adapted lipid composition and a cIMF, on body weight, glucose homoeostasis, liver and adipose tissue. Nutrient composition was similar for the eIMF and cIMF; the lipid fractions comprised approximately 50 % milk fat. C57BL/6JOlaHsd mice were fed cIMF or eIMF from postnatal day (PN) 16-42 followed by an HFD until PN168. Feeding eIMF v. cIMF in early life resulted in a lower body weight (-9 %) and body fat deposition (-14 %) in adulthood (PN105). The effect appeared transient, as from PN126 onwards, after 12 weeks' HFD, eIMF-fed mice caught up on controls and body and fat weights became comparable between groups. Glucose and energy metabolism were similar between groups. At dissection (PN168), eIMF-fed mice showed larger (+27 %) epididymal fat depots and a lower (-26 %) liver weight without clear morphological aberrations. Our data suggest the size and coating but not the lipid composition of IMF fat globules underlie the programming effect observed. Prolonged exposure to an HFD challenge partly overrules the programming effect of early diet. ispartof: BRITISH JOURNAL OF NUTRITION vol:122 issue:12 pages:1321-1328 ispartof: location:England status: published
- Published
- 2019
- Full Text
- View/download PDF