1. Intake ofn-3 fatty acids and long-term outcome in renal transplant recipients: apost hocanalysis of a prospective cohort study
- Author
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Ilse G. Pranger, Sabita S. Soedamah-Muthu, Eke G. Gruppen, Gerjan Navis, Michel M. Joosten, Ido P. Kema, Frits A. J. Muskiet, Stephan J. L. Bakker, Else van den Berg, Rijk O. B. Gans, Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), and Lifelong Learning, Education & Assessment Research Network (LEARN)
- Subjects
Graft Rejection ,Male ,Nutrition and Disease ,ALPHA-LINOLENIC ACID ,Medicine (miscellaneous) ,BLOOD-PRESSURE ,030204 cardiovascular system & hematology ,Renal transplant recipients ,Gastroenterology ,law.invention ,Cohort Studies ,0302 clinical medicine ,Randomized controlled trial ,law ,Interquartile range ,Voeding en Ziekte ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Netherlands ,RISK ,Nutrition and Dietetics ,Proteinuria ,Hazard ratio ,Middle Aged ,DESATURASES ,CONTROLLED-TRIALS ,Eicosapentaenoic Acid ,CARDIOVASCULAR-DISEASE ,Renal transplant ,SURVIVAL ,Female ,Graft failure ,medicine.symptom ,Adult ,medicine.medical_specialty ,Adolescent ,Docosahexaenoic Acids ,End Stage Liver Disease ,Young Adult ,03 medical and health sciences ,FISH ,Internal medicine ,Post-hoc analysis ,Humans ,N-3 fatty acids ,Mortality ,Aged ,Proportional Hazards Models ,VLAG ,n-3 Fatty acids ,business.industry ,Kidney Transplantation ,Diet ,Surgery ,Dietary Supplements ,Self Report ,business ,Follow-Up Studies ,OMEGA-3-FATTY-ACIDS - Abstract
Supplementation withn-3 fatty acids may improve long-term outcomes of renal transplant recipients (RTR). Recent evidence suggests that EPA and DHA have different outcomes compared withα-linolenic acid (ALA). We examined the prospective associations of EPA–DHA and ALA intakes with graft failure and all-cause mortality in 637 RTR. During 3·1 years (interquartile range 2·7, 3·8) of follow-up, forty-one developed graft failure and sixty-seven died. In age- and sex-adjusted analyses, EPA–DHA and ALA intakes were not associated with graft failure. EPA–DHA intake was not significantly associated with mortality (hazard ratio (HR) 0·79; 95% CI 0·54, 1·15 per 0·1 energy% difference). ALA intake was significantly associated with mortality (HR 1·17; 95% CI 1·04, 1·31 per 0·1 energy% difference). This association remained following adjustments for BMI, proteinuria and intakes of fat, carbohydrate and protein. RTR in the highest tertile of ALA intake exhibited about 2-fold higher mortality risk (HR 2·21; 95% CI 1·23, 3·97) compared with the lowest tertile. In conclusion, ALA intake may be associated with increased mortality in RTR. Future RCT are needed to confirm these results.
- Published
- 2016
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