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Start Over Author "Tait, R." Journal british journal of haematology
28 results on '"Tait, R."'

21. Peri-operative management of anticoagulation and antiplatelet therapy.

Author

Keeling, David, Tait, R. Campbell, and Watson, Henry

Subjects
*ANTICOAGULANTS, *HEMATOLOGIC agents, *PERIOPERATIVE care, *HEMOSTASIS, *BLOOD coagulation
Abstract

The article presents the British Committee for Standards in Haematology's (BSH) guide to the perioperative management of anticoagulation and antiplatelet therapy. Topics covered include whether anticoagulants and antiplatelet agents should be discontinued before elective surgery and invasive procedures, improvement of hemostasis, managing patients on vitamin K antagonists such as warfarin, and the use of direct oral anticoagulants.

Published
2016
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26. A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state.

Author

Dykes, Anne C., Walker, Isobel D., McMahon, Alex D., Islam, S. I. A. M., and Tait, R. C.

Subjects
PROTEIN S, ANTIGENS, DEFICIENCY diseases, AGE factors in disease, SEX factors in disease, HORMONE therapy complications
Abstract

Total Protein S (tPS) and free Protein S (fPS) antigen levels were measured in 3788 healthy blood donors. Men had higher levels of both parameters than women (P < 0·001). Age had no effect on tPS in men, although there was a slight reduction in fPS levels with increasing age. In women increasing age was associated with a significant increase in tPS levels (P < 0·001) but had no effect on fPS after adjustment for menopausal state. Oral contraceptive pill (OCP) use significantly lowered tPS but had no effect on fPS. In post-menopausal women, hormone replacement therapy (HRT) use had no statistically significant effect on either tPS or fPS. Donors with tPS or fPS levels in the lowest percentile (n = 56) were retested; only nine with repeat low levels were identified, eight of whom had persistently low levels over a 4–7-year follow-up. Acquired deficiency was excluded. When possible, family studies were performed, leading to an estimate of prevalence of familial PS deficiency of between 0·03% and 0·13% in the general population. [ABSTRACT FROM AUTHOR]

Published
2001
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