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Your search keyword '"Miyamura, Takako"' showing total 7 results
Start Over Author "Miyamura, Takako" Journal british journal of haematology
7 results on '"Miyamura, Takako"'

1. Impact of asparaginase discontinuation on outcomes of children with acute lymphoblastic leukaemia receiving the Japan Association of Childhood Leukaemia Study ALL ‐02 protocol

Author

Ishida, Hisashi, primary, Imamura, Toshihiko, additional, Tatebe, Yasuhisa, additional, Ishihara, Takashi, additional, Sakaguchi, Kimiyoshi, additional, Suenobu, Souichi, additional, Sato, Atsushi, additional, Hashii, Yoshiko, additional, Deguchi, Takao, additional, Takahashi, Yoshihiro, additional, Hasegawa, Daiichiro, additional, Miyamura, Takako, additional, Iguchi, Akihiro, additional, Kato, Koji, additional, Saito‐Moriya, Akiko, additional, Hara, Junichi, additional, and Horibe, Keizo, additional

Published
2023
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2. Haematopoietic cell transplantation for children with acute megakaryoblastic leukaemia without Down syndrome

Author

Hama, Asahito, primary, Taga, Takashi, additional, Tomizawa, Daisuke, additional, Muramatsu, Hideki, additional, Hasegawa, Daiichiro, additional, Adachi, Souichi, additional, Yoshida, Nao, additional, Noguchi, Maiko, additional, Sato, Maho, additional, Okada, Keiko, additional, Koh, Katsuyoshi, additional, Mitsui, Tetsuo, additional, Takahashi, Yoshiyuki, additional, Miyamura, Takako, additional, Hashii, Yoshiko, additional, Kato, Koji, additional, Atsuta, Yoshiko, additional, and Okamoto, Yasuhiro, additional

Published
2023
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3. Low NUDT15 expression levels due to biallelicNUDT15variants and 6‐mercaptopurine intolerance

Author

Yoshida, Masanori, primary, Brown, Scott A., additional, Moriyama, Takaya, additional, Nishii, Rina, additional, Tsujimoto, Shin‐ichi, additional, Yamada, Yuji, additional, Yoshida, Kaoru, additional, Shirai, Ryota, additional, Osumi, Tomoo, additional, Utano, Tomoyuki, additional, Fukano, Reiji, additional, Kudo, Ko, additional, Sakaguchi, Kimiyoshi, additional, Arakawa, Yuki, additional, Koh, Katsuyoshi, additional, Sekiguchi, Masahiro, additional, Sekimizu, Masahiro, additional, Miyamura, Takako, additional, Ishida, Hisashi, additional, Inukai, Takeshi, additional, Tomizawa, Daisuke, additional, Kiyokawa, Nobutaka, additional, Kato, Motohiro, additional, and Yang, Jun J., additional

Published
2022
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4. Low NUDT15 expression levels due to biallelic NUDT15 variants and 6‐mercaptopurine intolerance.

Author

Yoshida, Masanori, Brown, Scott A., Moriyama, Takaya, Nishii, Rina, Tsujimoto, Shin‐ichi, Yamada, Yuji, Yoshida, Kaoru, Shirai, Ryota, Osumi, Tomoo, Utano, Tomoyuki, Fukano, Reiji, Kudo, Ko, Sakaguchi, Kimiyoshi, Arakawa, Yuki, Koh, Katsuyoshi, Sekiguchi, Masahiro, Sekimizu, Masahiro, Miyamura, Takako, Ishida, Hisashi, and Inukai, Takeshi

Subjects
LEUCOCYTES, ENZYME-linked immunosorbent assay, LYMPHOBLASTIC leukemia, PROTEIN stability, ACUTE leukemia
Abstract

Summary: 6‐Mercaptopurine (6‐MP) is widely used for the treatment of paediatric leukaemia and lymphoma. Recently, germline variants in the NUDT15 gene have been identified as one of the major genetic causes for 6‐MP–associated adverse effects such as myelosuppression. Patients with hypomorphic NUDT15 variants accumulate excessive levels of DNA‐incorporated thioguanine in white blood cells, resulting in severe myelosuppression. Although preclinical studies suggest that these variants may influence the protein stability of NUDT15, this has not been directly characterised in patients. In this study, we report the development of a series of novel monoclonal antibodies against NUDT15, using which we quantitatively assessed NUDT15 protein levels in 37 patients with acute lymphoblastic leukaemia treated with 6‐MP, using sandwich enzyme‐linked immunosorbent assay (ELISA). The NUDT15 genotype was highly correlated with its protein levels (p < 0.0001), with homozygous and compound heterozygous patients showing exceedingly low NUDT15 expression. There was a positive correlation between NUDT15 protein level and 6‐MP tolerance (r = 0.631, p < 0.0001). In conclusion, our results point to low NUDT15 protein abundance as the biochemical basis for NUDT15‐mediated 6‐MP intolerance, thus providing a phenotypic readout of inherited NUDT15 deficiency. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Prevalence of germline GATA2 and SAMD9/9L variants in paediatric haematological disorders with monosomy 7

Author

Yoshida, Masanori, primary, Tanase‐Nakao, Kanako, additional, Shima, Hirohito, additional, Shirai, Ryota, additional, Yoshida, Kaoru, additional, Osumi, Tomoo, additional, Deguchi, Takao, additional, Mori, Makiko, additional, Arakawa, Yuki, additional, Takagi, Masatoshi, additional, Miyamura, Takako, additional, Sakaguchi, Kimiyoshi, additional, Toyoda, Hidemi, additional, Ishida, Hisashi, additional, Sakata, Naoki, additional, Imamura, Toshihiko, additional, Kawahara, Yuta, additional, Morimoto, Akira, additional, Koike, Takashi, additional, Yagasaki, Hiroshi, additional, Ito, Shuichi, additional, Tomizawa, Daisuke, additional, Kiyokawa, Nobutaka, additional, Narumi, Satoshi, additional, and Kato, Motohiro, additional

Published
2020
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6. Clinical and biological features of paediatric acute myeloid leukaemia ( AML ) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML ‐05 study

Author

Miyamura, Takako, primary, Moritake, Hiroshi, additional, Nakayama, Hideki, additional, Tanaka, Shiro, additional, Tomizawa, Daisuke, additional, Shiba, Norio, additional, Saito, Akiko M., additional, Tawa, Akio, additional, Shimada, Akira, additional, Iwamoto, Shotaro, additional, Hayashi, Yasuhide, additional, Koike, Takashi, additional, Horibe, Keizo, additional, Manabe, Atsushi, additional, Mizutani, Shuki, additional, Taga, Takashi, additional, and Adachi, Souichi, additional

Published
2019
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7. Frequent loss of HLA‐B*40:02 from leucocytes in male patients with hepatitis‐associated aplastic anaemia.

Author

Katagiri, Takamasa, Takahashi, Rio, Zaimoku, Yoshitaka, Hosokawa, Kohei, Ogawa, Seishi, Takahashi, Yoshiyuki, Miyamura, Takako, Onishi, Yasushi, Koike, Takashi, Nishida, Tetsuya, Uchida, Naoyuki, Doki, Noriko, Tanaka, Masatsugu, Eto, Tetsuya, Itagaki, Mitsuhiro, Sawa, Masashi, Fukuda, Takahiro, Onizuka, Makoto, Atsuta, Yoshiko, and Nakao, Shinji

Published
2024
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