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Summary: Mantle cell lymphoma is a rare and incurable lymphoproliferative disorder. In the MCL01 trial, patients were treated with the R‐HCVAD regimen [rituximab plus HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone; R‐CVAD) alternating with high‐dose methotrexate and cytarabine (AM)] for four cycles followed by autologous stem cell transplantation (ASCT) for those who reached only a partial response. After a median follow‐up of 10·5 years, we reported 10‐year progression‐free and overall survival rates of 35% and 61% respectively, with a 10‐years cumulative incidence rate of second malignancies of 10·6%. Mature results of the MCL01 trial confirmed the efficacy of HyperCVAD‐AM as a frontline regimen for younger patients (≤65 years). [ABSTRACT FROM AUTHOR]

The article presents a study that investigated if a pattern of molecular response (MR) instability could affect overall survival (OS) and failure-free survival in a series of chronic myeloid leukaemia(CP-CML) patients who received imatinib for a median follow-up of 7 years. Topics discussed include analysis of the patients for mutational screening with Sanger sequencing analysis and the association of MR3 with increased probability of developing resistance to imatinib.