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This article discusses a study on a rare genetic disorder called ETV6-related thrombocytopenia (ETV6-RT). The study examined the platelets of twelve patients with ETV6-RT and found that they had an increased expression of the ETV6 protein, which is transferred from bone marrow megakaryocytes to platelets. The study also observed alterations in δ-granule markers in some patients, indicating a potential δ-storage pool disorder. The findings suggest that immunofluorescence microscopy can be used as a screening tool for ETV6-RT, especially in cases of mild-to-moderate thrombocytopenia with normal platelet size. However, further research is needed to confirm these findings and validate them as a specific signature of the disease. [Extracted from the article]