12 results on '"Junji Suzumiya"'
Search Results
2. Haematopoietic stem cell transplantation for relapsed or refractory anaplastic large cell lymphoma: a study of children and adolescents in Japan
- Author
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Hiroaki Goto, Ritsuro Suzuki, Tetsuo Mitsui, Reiji Fukano, Junji Suzumiya, Souichi Adachi, Naoto Fujita, Ryoji Kobayashi, Hisashi Sakamaki, Keisei Kawa, Koji Kato, Tetsuya Mori, Fuminori Iwasaki, Yong Dong Park, Junichi Hara, Masami Inoue, Jiro Inagaki, Yuhki Koga, Motoaki Chin, and Yoshiyuki Takahashi
- Subjects
Oncology ,medicine.medical_specialty ,Transplantation Conditioning ,Adolescent ,Graft vs Host Disease ,Transplantation, Autologous ,Refractory Anaplastic Large Cell Lymphoma ,Disease-Free Survival ,Japan ,Recurrence ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Cumulative incidence ,Child ,Anaplastic large-cell lymphoma ,Retrospective Studies ,Salvage Therapy ,business.industry ,Incidence ,Hematopoietic Stem Cell Transplantation ,Hematology ,Allografts ,medicine.disease ,Combined Modality Therapy ,Surgery ,Transplantation ,Haematopoiesis ,surgical procedures, operative ,Drug Resistance, Neoplasm ,Allogeneic hsct ,Lymphoma, Large-Cell, Anaplastic ,Conventional chemotherapy ,Stem cell ,business - Abstract
To evaluate haematopoietic stem cell transplantation (HSCT) in children and adolescents, we reviewed the records of 47 patients who were ≤18 years, had relapsed or refractory anaplastic large cell lymphoma, and received HSCT between 1990 and 2010. At HSCT, complete remission (CR) was less common in allogeneic HSCT recipients (n = 24) than in autologous HSCT recipients (n = 23) (P = 0·01). The autologous and allogeneic HSCT groups differed in terms of 5-year event-free survival (EFS) (38% vs. 50%, P = 0·63), cumulative incidence of progress or relapse (49% vs. 28%, P = 0·25), and treatment-related mortality (12% vs. 25%, P = 0·40). However, these differences were not significant. Patients with non-CR at autologous HSCT had a significantly lower EFS rate (14% vs. 48%, P = 0·03). Conversely, although those with non-CR at allogeneic HSCT had a lower EFS rate, this was not significant (44% vs. 63%, P = 0·26). Reduced-intensity conditioning regimens were used for three of the 16 allogeneic HSCTs received by patients with non-CR. These three patients achieved CR, surviving 32-65 months after HSCT. These results demonstrated that allogeneic HSCT might be a treatment option for patients who do not achieve CR through conventional chemotherapy.
- Published
- 2014
3. Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan
- Author
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Hirokazu Okumura, Ritsuro Suzuki, Ryoji Kobayashi, Yasushi Takeshita, Koji Kato, Hiromasa Yabe, Ryosei Nishimura, Naoto Fujita, Hisashi Sakamaki, Tetsuo Mitsui, Youji Sasahara, Fuminori Iwasaki, Hiroshi Kuroda, Keisuke Kato, Junji Suzumiya, and Keisei Kawa
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Adolescent ,T cell ,Disease-Free Survival ,Japan ,Internal medicine ,medicine ,Humans ,T-cell lymphoma ,Child ,Survival rate ,business.industry ,Not Otherwise Specified ,Infant, Newborn ,Infant ,Lymphoma, T-Cell, Peripheral ,Hematology ,medicine.disease ,Peripheral T-cell lymphoma ,Surgery ,Lymphoma ,Survival Rate ,Transplantation ,surgical procedures, operative ,medicine.anatomical_structure ,Child, Preschool ,Female ,Stem cell ,business ,Stem Cell Transplantation - Abstract
Summary Reports of non-anaplastic peripheral T-cell lymphoma (PTCL) in paediatric patients, especially results of stem cell transplantation (SCT), are relatively rare. We herein report the results of SCT using the Transplant Registry Unified Management Program system of the Japanese Society of Stem Cell Transplantation in paediatric patients with non-anaplastic PTCL. We analysed 26 patients (13 females and 13 males) aged 18 years with nonanaplastic PTCL who underwent a total of 28 SCT. Median age at transplantation was 135 years (range: 0–18 years). PTCL not otherwise specified was diagnosed in 17 patients; extranodal Natural Killer (NK)/T cell lymphoma, nasal type in nine; and subcutaneous panniculitis-like T-cell lymphoma in two. Transplantation was with syngeneic donor in one, related donor in 10; unrelated donor in 10; and auto transplantation in 7. Fiveyear overall survival rate and event-free survival rate was 6296% and 5556%, respectively. Male gender, chronic graft-versus-host disease (GVHD), and reduced intensity conditioning were good prognostic factors in all patients. In 20 patients with refractory or relapsed disease, male gender and chronic GVHD were also good prognostic factors. This study is the first report concerning transplantation in children with non-anaplastic PTCL, although the number of patients was small. Larger studies are needed to confirm these findings.
- Published
- 2012
4. Expression of FoxP3, a key molecule in CD4+ CD25+ regulatory T cells, in adult T-cell leukaemia/lymphoma cells
- Author
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Koichi Ohshima, Kennosuke Karube, Riko Kawano, Junji Suzumiya, Atae Utsunomiya, Takahiro Yamaguchi, Mine Harada, Masahiro Kikuchi, and Takeshi Tsuchiya
- Subjects
medicine.medical_specialty ,Hematology ,Effector ,FOXP3 ,hemic and immune systems ,chemical and pharmacologic phenomena ,T lymphocyte ,Biology ,medicine.disease ,Lymphoma ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,Internal medicine ,Immunology ,medicine ,Cancer research ,IL-2 receptor ,Lymph node ,Immunostaining - Abstract
Summary Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4+CD25+ phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.
- Published
- 2004
5. Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma
- Author
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Nozomi Niitsu, Tadashi Yoshino, Tadaatsu Akagi, Koichi Ohshima, Mine Harada, Yoshito Sadahira, Masahiro Kikuchi, Katsuji Shinagawa, Mitsune Tanimoto, Junjiro Tsuchiyama, Junji Suzumiya, and Shigeo Nakamura
- Subjects
Univariate analysis ,integumentary system ,T cell ,food and beverages ,Hematology ,Biology ,medicine.disease ,Nose neoplasm ,Lymphoma ,medicine.anatomical_structure ,Antigen ,Immunology ,medicine ,Neoplasm ,Immunohistochemistry ,lipids (amino acids, peptides, and proteins) ,Survival analysis - Abstract
Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n=29) had a much worse prognosis than the CLA- group (n=23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.
- Published
- 2002
6. Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes
- Author
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K. Shimazaki, K. Ohshima, Masahiro Kikuchi, Chika Kawasaki, and Junji Suzumiya
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Myelodysplastic syndromes ,CD34 ,Hematology ,medicine.disease ,Pancytopenia ,Haematopoiesis ,Leukemia ,medicine.anatomical_structure ,hemic and lymphatic diseases ,Medicine ,Bone marrow ,Stem cell ,business ,Survival rate - Abstract
The myelodysplastic syndromes (MDS) are a group of disorders characterized by peripheral pancytopenia despite normo- or hypercellular bone marrow. This is thought to be as a result of the apoptosis of haematopoietic bone marrow cells resulting in ineffective haematopoiesis. To clarify the relationship between prognosis and apoptosis and/or cell proliferation in the bone marrow, we studied 51 cases with MDS. Bone marrow biopsies were stained immunohistochemically for MIB-1 (marker for proliferating cells) and CD34 (marker for stem cells). Apoptosis was visualized by detection of DNA fragmentation using TdT incorporation of nucleotides on 3' ends of DNA (TUNEL technique) and expressed as the apoptotic rate. MDS patients included 32 with refractory anaemia (RA), one RA with ringed sideroblasts (RARS) patient, seven RA with excess of blasts (RAEB) patients, eight patients with RAEB in transformation (RAEB-t) and three patients with chronic myelomonocytic leukaemia (CMMoL). In addition, we also studied six cases with acute myeloid leukaemia (AML) arising from MDS (AML-MDS) and ten control subjects. Fatal pancytopenia was the cause of death in 19 out of 51 patients. The apoptotic rate was higher in MDS patients (5.5%) than in control subjects (0.6%) and AML-MDS patients (0.4%). The percentage of MIB-1 positive cells was higher in MDS and AML-MDS than in control. The percentage of CD34-positive cells was higher in AML-MDS, RAEB, RAEB-t and CMMoL patients than control subjects and RA patients. Our findings indicate the activation of both the proliferative and apoptotic rates in MDS. Poor prognosis correlated significantly with higher apoptotic rates, but not with percentages of MIB-1 and CD34-positive cells. Our results suggest that apoptosis might be a useful prognostic factor and inhibition of apoptotic mechanisms may induce leukaemic transformation in MDS.
- Published
- 2000
7. Myelodysplastic syndrome in a patient with adult T-cell leukaemia
- Author
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K. Ohshima, Shogo Takeuchi, Junji Suzumiya, Hisashi Kawabata, Shigeo Horiike, Atae Utsunomiya, Yoshifusa Takatsuka, Torahiko Makino, Shuichi Hanada, and Shinsuke Suzuki
- Subjects
medicine.medical_specialty ,Pathology ,Chemotherapy ,biology ,business.industry ,viruses ,medicine.medical_treatment ,Cytogenetics ,Hematology ,Human T-lymphotropic virus ,medicine.disease ,biology.organism_classification ,Virus ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,Immunology ,Monoclonal ,Chromosome abnormality ,Medicine ,Bone marrow ,Viral disease ,business - Abstract
A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described. The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t-MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13). Although monoclonal integration of human T lymphotropic virus type I (HTLV-I) proviral DNA was detected in the peripheral blood lymphocytes at ATL diagnosis, bone marrow cells at t-MDS diagnosis did not show monoclonal integration of HTLV-I. To our knowledge, this is the first report of t-MDS associated with ATL.
- Published
- 1999
8. Nodal T‐cell lymphoma in an HTLV‐I‐endemic area: proviral HTLV‐I DNA, histological classification and clinical evaluation
- Author
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Kensaku Sato, Seiji Haraoka, Midori Sugihara, Motonobu Kanda, Morishige Takeshita, Junji Suzumiya, Masahiro Kikuchi, and Koichi Ohshima
- Subjects
Pathology ,medicine.medical_specialty ,Virus Integration ,Biology ,Lymphoma, T-Cell ,Malignancy ,Polymerase Chain Reaction ,immune system diseases ,hemic and lymphatic diseases ,Genotype ,medicine ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,T-cell lymphoma ,Lymph node ,Survival rate ,Survival analysis ,Large cell ,Hematology ,medicine.disease ,HTLV-I Infections ,Immunohistochemistry ,Survival Analysis ,Lymphoma ,Survival Rate ,Blotting, Southern ,medicine.anatomical_structure ,DNA, Viral ,Immunology - Abstract
Adult T-cell leukaemia/lymphoma (ATLL) is a human malignancy associated with human T-cell leukaemia virus type I (HTLV-I). The histology usually indicates a pleomorphic type, but is not consistent. To clarify the relationship between the histological classification and prognosis in ATLL, and to confirm the significance of clonal HTLV-I integration, we reclassified 572 cases with nodal T-cell lymphoma in which the T-cell phenotype and/or genotype was confirmed. In all cases the clonal integration of HTLV-I proviral DNA in the lymph nodes was examined by Southern blot analysis. In addition, anti-ATL antigen (ATLA) determination in the serum or PCR analysis of HTLV-I pX amplification in lymph nodes was also performed. 66/313 (21%) cases with ATLA had no evidence of clonal HTLV-I integration. 572 cases were classified into three groups: (A) cases with clonal integration (247 cases), (B) cases with ATLA without clonal integration of HTLV-I proviral DNA (66 cases), (C) cases without ATLA (259 cases). Histologically, groups B and C frequently demonstrated large cell type and angioimmunoblastic lymphadenopathy with dysproteinaemia (AILD) type; however, group A tended to show a pleomorphic type. Clinically, group A showed a poorer prognosis than groups B and C. In conclusion, group A cases were defined as ATLL (HTLV-I-associated T-cell lymphoma), whereas group B was classified as T-cell lymphoma, which had coincidently occurred in HTLV-I infected carriers. The simplified classification of REAL indicated clinical outcome: the prognosis of ATLL was poor, the unspecified type was intermediate, whereas the other types of lymphoblastic, AILD and anaplastic large cell type were all relatively favourable.
- Published
- 1998
9. Prognostic significance of hepatocyte growth factor and c-MET expression in patients with diffuse large B-cell lymphoma
- Author
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Koichi Ohshima, Kennosuke Karube, Kazuo Tamura, Takahiro Yamaguchi, Masahiro Kikuchi, S Kohno, Junji Suzumiya, and Riko Kawano
- Subjects
Adult ,Male ,medicine.medical_specialty ,C-Met ,Adolescent ,Proto-Oncogene Mas ,Gastroenterology ,chemistry.chemical_compound ,International Prognostic Index ,Internal medicine ,medicine ,Humans ,Receptor ,Aged ,Aged, 80 and over ,Hematology ,Hepatocyte Growth Factor ,business.industry ,Large-cell lymphoma ,Middle Aged ,Proto-Oncogene Proteins c-met ,Prognosis ,medicine.disease ,Immunohistochemistry ,Survival Analysis ,Lymphoma ,chemistry ,Cancer research ,Female ,Hepatocyte growth factor ,Lymphoma, Large B-Cell, Diffuse ,business ,Diffuse large B-cell lymphoma ,medicine.drug - Abstract
Summary The expression and prognostic significance of hepatocyte growth factor (HGF) and its receptor c-MET (MET proto-oncogene) was analysed in 96 cases of diffuse large B-cell lymphoma (DLBCL). Tissue sections were immunohistochemically stained for HGF and c-Met. The prognosis of HGF-positive and c-Met-positive cases was significantly worse than negative cases (HGF: P = 0·0036; c-Met: P = 0·0002). In addition, in the low-risk international prognostic index group, HGF-negative and c-Met-negative cases had a significantly better prognosis than positive cases (HGF: P = 0·0009; c-Met: P
- Published
- 2004
10. Elevated serum soluble Fas ligand in natural killer cell proliferative disorders
- Author
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Junji Suzumiya, Keizo Anzai, Kei Kato, Koichi Ohshima, Masahiro Kikuchi, and Shigehiko Ishihara
- Subjects
medicine.medical_treatment ,Lymphocyte ,Hematology ,Biology ,medicine.disease ,Soluble fas ligand ,Lymphoma ,Natural killer cell ,Elevated serum ,Leukemia ,Cytokine ,medicine.anatomical_structure ,hemic and lymphatic diseases ,Immunology ,medicine ,In patient - Abstract
We evaluated the serum level of soluble Fas ligand (sFasL) in patients with natural killer lymphocyte proliferative disorders (NK- LPD). The serum sFasL level was elevated in neoplastic groups of aggressive NK leukaemia, indolent NK leukaemia and NK lymphoma, all of which contained clonal EBV-DNA. In NK leukaemia the serum sFasL level was significantly higher than that found in others. However, it was not elevated in the patients with reactive NK-LPD and in one patient with NK leukaemia in remission. These findings indicate that the serum sFasL level is a useful indicator in evaluating disease activity.
- Published
- 1998
11. Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells
- Author
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Kennosuke, Karube, Koichi, Ohshima, Takeshi, Tsuchiya, Takahiro, Yamaguchi, Riko, Kawano, Junji, Suzumiya, Atae, Utsunomiya, Mine, Harada, and Masahiro, Kikuchi
- Subjects
Adult ,Male ,Reverse Transcriptase Polymerase Chain Reaction ,T-Lymphocytes ,Forkhead Transcription Factors ,Receptors, Interleukin-2 ,Middle Aged ,Immunohistochemistry ,DNA-Binding Proteins ,CD4 Antigens ,Humans ,Leukemia-Lymphoma, Adult T-Cell ,Female ,Biomarkers ,Aged - Abstract
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.
- Published
- 2004
12. Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma
- Author
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Tadashi, Yoshino, Shigeo, Nakamura, Junji, Suzumiya, Nozomi, Niitsu, Koichi, Ohshima, Junjiro, Tsuchiyama, Katsuji, Shinagawa, Mitsune, Tanimoto, Yoshito, Sadahira, Mine, Harada, Masahiro, Kikuchi, and Tadaatsu, Akagi
- Subjects
Adult ,Aged, 80 and over ,Antigens, Differentiation, T-Lymphocyte ,Male ,Membrane Glycoproteins ,Skin Neoplasms ,Adolescent ,Nose Neoplasms ,Middle Aged ,Prognosis ,Immunohistochemistry ,Survival Analysis ,Lymphoma, T-Cell, Cutaneous ,Killer Cells, Natural ,Antigens, Neoplasm ,Antineoplastic Combined Chemotherapy Protocols ,Multivariate Analysis ,Humans ,Female ,Aged - Abstract
Nasal and nasal-type natural killer (NK) lymphoma is a distinct clinicopathological entity mostly associated with Epstein-Barr virus. Cases that have widespread lesions are resistant to ordinary anti-cancer therapy and take a highly aggressive course. To date, there are no available data on the relationships between the localization, clinical outcome and expression of adhesion molecules in such cases. We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. CLA was highly expressed in cutaneous cases. Also, the CLA+ group (n=29) had a much worse prognosis than the CLA- group (n=23), regardless of the primary site or clinical staging. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors showed that the expression of CLA was an independent prognostic indicator. In conclusion, the present findings established that CLA is an independent and important prognostic factor in patients with NK-cell lymphomas.
- Published
- 2002
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