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Start Over Author "Goldaniga M" Journal british journal of haematology
5 results on '"Goldaniga M"'

2. Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients

Author

Massimo Freschi, Antonino Neri, Francesco Bertolini, Giancarlo Pruneri, Maria Goldaniga, Nadia Carboni, Maurilio Ponzoni, Giuseppe Viale, Nicola Decarli, Luca Baldini, Andrés J.M. Ferreri, Chiara Baldessari, Moreno Tresoldi, Francesca Raggi, Pruneri, G, Ponzoni, Maurilio, Ferreri, Ajm, Decarli, N, Tresoldi, M, Raggi, F, Baldessari, C, Freschi, M, Baldini, L, Goldaniga, M, Neri, A, Carboni, N, Bertolini, F, and Viale, G.

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Angiogenesis, CD34, Vascular Cell Adhesion Molecule-1, Antigens, CD34, Receptors, Cell Surface, Neovascularization, Antigens, CD, Biomarkers, Tumor, medicine, Humans, Survival rate, Multiple myeloma, Aged, Aged, 80 and over, Neovascularization, Pathologic, business.industry, Microcirculation, Endoglin, Antibodies, Monoclonal, Hematology, Middle Aged, Prognosis, medicine.disease, digestive system diseases, Survival Rate, medicine.anatomical_structure, Multivariate Analysis, cardiovascular system, Immunohistochemistry, Female, Bone marrow, medicine.symptom, Multiple Myeloma, business, Follow-Up Studies
Abstract

We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34(+) MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105(+) MVD. Multivariate analysis confirmed the independent significant association between CD34(+) MVD and survival (P = 0.001).

Published
2002
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3. Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias.

Author

Luminari S, Goldaniga M, Ceccherelli F, Guffanti A, Bombardieri E, Marcheselli R, Cro L, Colombi M, Federico M, and Baldini L

Subjects
Adult, Aged, Aged, 80 and over, Humans, Middle Aged, Paraproteinemias mortality, Prognosis, Survival Analysis, Mucin-1 metabolism, Paraproteinemias blood
Abstract

High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).

Published
2003
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4. Angiogenesis occurs in hairy cell leukaemia (HCL) and in NOD/SCID mice transplanted with the HCL line Bonna-12.

Author

Pruneri G, Bertolini F, Baldini L, Valentini S, Goldaniga M, Soligo D, Carboni N, Viale G, and Lambertenghi-Deliliers G

Subjects
Adult, Aged, Angiogenesis Inhibitors therapeutic use, Animals, Antineoplastic Agents therapeutic use, Female, Humans, Interferon-alpha therapeutic use, Leukemia, Hairy Cell drug therapy, Male, Mice, Mice, Inbred NOD, Mice, SCID, Microcirculation, Middle Aged, Neoplasm Transplantation, Tumor Cells, Cultured, Bone Marrow blood supply, Leukemia, Hairy Cell pathology, Neovascularization, Pathologic pathology
Abstract

Microvessel density (MVD), a surrogate marker for angiogenesis, was evaluated by anti-CD34 and CD105 monoclonal antibodies (Abs), and found to be increased in the bone marrow (BM) of hairy cell leukaemia (HCL) patients and in a preclinical model of non-obese diabetic/severe combined immunodeficient mice transplanted with the HCL line Bonna-12. The anti-CD105 Ab was significantly more sensitive than anti-CD34 Ab in identifying blood vessels. The BM tumour burden significantly decreased in patients treated with interferon-alpha, but the mean value of MVD remained unchanged. These data suggest that angiogenesis may be involved in the pathogenesis of HCL.

Published
2003
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5. Microvessel density, a surrogate marker of angiogenesis, is significantly related to survival in multiple myeloma patients.

Author

Pruneri G, Ponzoni M, Ferreri AJ, Decarli N, Tresoldi M, Raggi F, Baldessari C, Freschi M, Baldini L, Goldaniga M, Neri A, Carboni N, Bertolini F, and Viale G

Subjects
Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal immunology, Antigens, CD, Endoglin, Female, Follow-Up Studies, Humans, Male, Microcirculation, Middle Aged, Multivariate Analysis, Prognosis, Receptors, Cell Surface, Survival Rate, Vascular Cell Adhesion Molecule-1 analysis, Antigens, CD34 analysis, Biomarkers, Tumor analysis, Multiple Myeloma blood supply, Neovascularization, Pathologic pathology
Abstract

We evaluated microvessel density (MVD) in bone marrow biopsies (BM) from multiple myeloma (MM) patients after staining with anti-CD34 and anti-CD105 antibodies (mAbs). The anti-CD105 mAb was significantly more sensitive than the anti-CD34 mAb in visualizing blood vessels both in controls and MM samples. MVD was significantly higher in MM than in controls with both anti-CD34 and anti-CD105 mAbs. Patients with low CD34+ MVD survived longer than patients with higher MVD (P = 0.01), whereas there was no difference in survival between patients with low and high CD105+ MVD. Multivariate analysis confirmed the independent significant association between CD34+ MVD and survival (P = 0.001).

Published
2002
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