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Start Over Author "Chermat A" Journal british journal of haematology
5 results on '"Chermat A"'

1. A randomised phase <scp>II</scp> study of azacitidine ( <scp>AZA</scp> ) alone or with Lenalidomide ( <scp>LEN</scp> ), Valproic acid ( <scp>VPA</scp> ) or Idarubicin ( <scp>IDA</scp> ) in <scp>higher‐Risk MDS</scp> or low blast <scp>AML</scp> : <scp>GFM</scp> 's 'pick a winner' trial, with the impact of somatic mutations

Author

Lionel Adès, Nicolas Duployez, Agnes Guerci‐Bresler, Kamel Laribi, Pierre Peterlin, Norbert Vey, Sylvain Thepot, Stefan Wickenhauser, Hacene Zerazhi, Aspassia Stamatoullas, Eric Wattel, Christian Recher, Andrea Toma, Sophie Dimicoli‐Salazar, Thorsten Braun, Odile Beyne‐Rauzy, Jean‐Pierre Marolleau, Stéphane Cheze, Sophie Park, Thomas Cluzeau, Stanislas Nimubona, Dominique Bordessoule, Riad Benramdane, Bruno Quesnel, Shanti Amé, Stéphane de Botton, Fathia Chermat, Claude Preudhomme, Sylvie Chevret, and Pierre Fenaux

Subjects
Hematology
Published
2022

3. A randomised phase II study of azacitidine (AZA) alone or with Lenalidomide (LEN), Valproic acid (VPA) or Idarubicin (IDA) in higher‐Risk MDS or low blast AML: GFM's “pick a winner” trial, with the impact of somatic mutations

Author

Adès, Lionel, primary, Duployez, Nicolas, additional, Guerci‐Bresler, Agnes, additional, Laribi, Kamel, additional, Peterlin, Pierre, additional, Vey, Norbert, additional, Thepot, Sylvain, additional, Wickenhauser, Stefan, additional, Zerazhi, Hacene, additional, Stamatoullas, Aspassia, additional, Wattel, Eric, additional, Recher, Christian, additional, Toma, Andrea, additional, Dimicoli‐Salazar, Sophie, additional, Braun, Thorsten, additional, Beyne‐Rauzy, Odile, additional, Marolleau, Jean‐Pierre, additional, Cheze, Stéphane, additional, Park, Sophie, additional, Cluzeau, Thomas, additional, Nimubona, Stanislas, additional, Bordessoule, Dominique, additional, Benramdane, Riad, additional, Quesnel, Bruno, additional, Amé, Shanti, additional, de Botton, Stéphane, additional, Chermat, Fathia, additional, Preudhomme, Claude, additional, Chevret, Sylvie, additional, and Fenaux, Pierre, additional

Published
2022
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4. Addition of suberoylanilide hydroxamic acid (Vorinostat) to azacitidine for patients with higher risk myelodysplastic syndromes and azacitidine failure: a phase II add-on study from the Groupe Francophone des Myelodysplasies

Author

Pierre Fenaux, Julie Lejeune, Stephan Wickenhauser, Norbert Vey, Fatiha Chermat, Pascale Cony-Makhoul, Eric Wattel, Jacques Delaunay, Thomas Prebet, Sylvie Chevret, Thorsten Braun, and Sophie Dimicoli

Subjects
0301 basic medicine, business.industry, Myelodysplastic syndromes, Azacitidine, Hematology, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Suberoylanilide Hydroxamic Acid, medicine, Cancer research, Myeloid leukaemia, business, Vorinostat, medicine.drug
Published
2016

5. You have free access to this contentAddition of suberoylanilide hydroxamic acid (Vorinostat) to azacitidine for patients with higher risk myelodysplastic syndromes and azacitidine failure: a phase II add-on study from the Groupe Francophone des Myelodysplasies.

Author

Prebet, Thomas, Delaunay, Jacques, Wattel, Eric, Braun, Thorsten, Cony‐Makhoul, Pascale, Dimicoli, Sophie, Wickenhauser, Stephan, Lejeune, Julie, Chevret, Sylvie, Chermat, Fatiha, Fenaux, Pierre, and Vey, Norbert

Subjects
HYDROXAMIC acids, AZACITIDINE, MYELODYSPLASTIC syndromes, DNA methylation, HISTONE deacetylase, GENE silencing, THERAPEUTICS
Abstract

The article looks at a study regarding the addition of suberoylanilide hydroxamic acid to azacitidine for patients with higher risk myelodysplastic syndromes and azacitidine failure. It mentions DNA methylation and histone deacetylation (HDAC) are synergistic in terms of gene silencing and the combination of inhibitors. It also mentions toxicity and efficacy of new drugs in combination with hypomethylating agents (HMAs).

Published
2018
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