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A recent study published in the British Journal of Dermatology discusses the use of beremagene geperpavec (B-VEC) gene therapy for the treatment of cutaneous wounds in patients with dystrophic epidermolysis bullosa (DEB). DEB is a rare inherited skin disease characterized by blistering and slow-to-heal wounds. The study found that B-VEC treatment resulted in significantly higher rates of wound healing compared to a placebo. The therapy has received approval from the US Food and Drug Administration and is expected to provide a new treatment option for patients with DEB. [Extracted from the article]

Two groups of patients were studied, one with known contact allergy to colophony and hand eczema, ‘colophony patients’, and the other consisted of patients who suspected that their eczema was caused by contact with paper, ‘paper patients’. The ‘colophony patients’ were patch tested with samples of newsprint paper, while the ‘paper patients’ were tested with samples of their own paper. Extracts of the paper and paper were applied. Testing with paper caused no reactions. All ‘colophony patients’ showed strong reactions to the tested extracts of newsprint paper. None of the ‘paper patients’ reacted to the extracts of their own paper, except those patch-test positive to colophony or maleopimaric acid, the main component of one type of modified colophony in paper size and shown experimentally to be a potent sensitizer. Colophony in paper may contribute to hand eczema in sensitized patients and the use of cotton gloves when in contact with paper might alleviate the dermatitis. [ABSTRACT FROM AUTHOR]

The proportion of patients with at least minimal improvement in TIS was significantly greater for those who received IVIG relative to placebo. A similar issue of emphasis on patients with muscle involvement arises in using TIS as the primary outcome measure. These results led to US Food and Drug Administration (FDA) approval of IVIG use in treating DM. [Extracted from the article]

Three discontinued the trial in the intervention arm, compared with one in the placebo arm. Bachelez and colleagues have reported their phase II placebo-controlled trial of intravenous spesolimab, an anti-interleukin (IL)-36 receptor monoclonal antibody, in generalized pustular psoriasis (GPP).[1] Fifty-three patients (aged 18-75 years, 68% female, 51% Asian) with a moderate-to-severe GPP flare were enrolled in the 1-week trial. A greater proportion of the spesolimab-treated group achieved GPPGA pustulation score 0 compared with those receiving placebo (54% vs. 6%, I P i < 0-001) and GPPGA clear or almost clear (43% vs. 11%, I P i = 0-02) at 1 week. [Extracted from the article]

Background The use of patient-reported outcome measures in electronic format has been increasing. However, these formats are usually not validated or compared with the original paper-based formats, so there is no evidence that they are completed in the same way. Objectives To compare the conventional paper version with a web-based application ( iPad®) version of the Dermatology Life Quality Index ( DLQI) to assess equivalence of scores. Methods The study employed a randomized crossover design using a within-subjects comparison of the two formats of the questionnaire. International Society for Pharmacoeconomics and Outcomes Research ( ISPOR) guidelines were followed. Participants aged over 18 years with any confirmed skin condition were recruited from a teaching hospital dermatology outpatient clinic. Expected intraclass correlation coefficient ( ICC) was 0·9 (α = 0·05). Results A total of 104 patients were recruited, median age 53·5 years (interquartile range 37·3-67·8; 43% male). The ICC showed high concordance between the total DLQI scores from paper and iPad versions ( ICC 0·98; 95% confidence interval 0·97-0·99). Patients took a median of 78 s to complete the electronic version and 73 s for paper ( P = 0·008): 76% preferred the electronic version and perceived completion to take a shorter time. Conclusions There is high concordance and thus equivalence between the iPad and paper versions of the DLQI, with an ICC of 0·98, and a clear patient preference for the iPad version. [ABSTRACT FROM AUTHOR]

Presents a subject index for the December 1991 issue of the "British Journal of Dermatology."

Introduction The use of structured questionnaires is common in patients with atopic dermatitis. Traditionally, this is done by paper-based questionnaires in clinics. Since the SARS-CoV-2 pandemic, many regard the shift from paper to digital forms as inevitable in order to improve efficiency, sustainability and reduce the risk of transmission. Objective This study aims to examine the feasibility and acceptability of pre-visit digital questionnaires in paediatric dermatology clinics. Methods Text message invitations to complete online questionnaires were sent to all patients who are due to attend a paediatric dermatology clinic at Nottingham University Hospitals. Results 1,218 responses were received between Sept 2021 and Mar 2022. 338 patients were reported to have eczema as their main skin complaint (71 new patients, 267 follow-ups). Amongst these, 113 patients were under 4 years old, 136 were between 4-12 years old and 89 were aged 13 or above. The average patient reported eczema severity was recorded as 12.6 +/– 7.8 SD using the Patient Oriented Eczema Measure (POEM) questionnaire. The majority of the questionnaires were filled in by the parents and required less than 5min to complete. 97.5% reported that they found the online questionnaire easier to use when compared to the paper format. Most participants and clinicians also reported they feel the online questionnaire enhanced their experience and consultation in the clinic. Conclusions Digital pre-visit online questionnaires are an acceptable method to gather information from parents of children with atopic dermatitis. Further work is required to assess the accuracy and clinical usefulness of the data. [ABSTRACT FROM AUTHOR]

Provides supplementary information on topics related to dermatology which appeared in the December 1993 issue of "British Journal of Dermatology."

HISTOCHEMICAL methods have been widely used in studies on the hair follicle but the possibilities of paper chromatography to detect extractable substances have been less fully exploited. Ellis, Gillespie and Lindley (1950) made use of the method in their work on wool follicles which were obtained in considerable quantity by Ellis' (1948) wax technique for removing hair roots from excised skin. In the present work, much smaller amounts of material obtained by plucking human scalp hair are shown to be accessible to analysis by paper chromatography. It was hoped that by this procedure chemical differences associated with pigmentary variations might be detected. [ABSTRACT FROM AUTHOR]

The article presents a list of topics published in the December 1994 issue of the journal "British Journal of Dermatology." Topics that are included range from summaries to correspondence, book reviews to indices. "Effects of Benzoyl Peroxide and Erythromycin Against Skin Bacteria," " Long-Term Safety of Isotretinoin Therapy," "Rotational Antibiotic Therapy and Staphylococcal Resistance," a case report on "Disseminated Superficial Porokeratosis," correspondence on "Allopurinol, Toxic Pustuloderma Induced by."

The article presents the summaries of papers on dermatology presented at the main plenary sessions. The National Health Service (NHS) Plan 2000 proposed the development of specialist general practitioners (GPs) to take referrals from other GPs in specialties including dermatology. The NHS Modernization Agency Action on Dermatology program funded pilot site studies of dermatology GPwSI, services and preliminary results were encouraging. By the end of 2005, all referrals from primary care will be performed electronically using a referral template. Currently only a proportion of referrals are electronic, allowing comparison with established paper referrals.

Presents the subject index for the December 1, 1995 issue of "British Journal of Dermatology."

The article presents the summaries of papers on dermatology presented at the Registrars Symposium. The longest follow-up study of oral retinoids for disorders of keratinization (DOK) up to now is 10 years. The aim of the study was to assess long-term disease response and side-effects in a cohort of patients with DOK, who were among the first in the world to commence oral retinoids 25 years ago.

The article presents the summaries of papers on clinicopathological cases related to dermatology. Congenital melanocytic naevi occur in 0.6-1.6% of newborns, but the exact incidence of giant congenital melanocytic naevi within the paediatric population is unknown. These rare cutaneous hamartomas of naevomelanocytes, often defined as a lesion, 20cm in diameter, are usually covered with hair. Soft tissue sarcomas are rare and both dermatologists and surgeons are unlikely to encounter many during their career. It is thus essential that physicians remain alert to these tumours as they behave aggressively.

The article presents the summaries of papers related to contact dermatitis. The most relevant allergological trigger factors of atopic eczema (AE) are food allergens and aeroallergens. Although IgE-mediated sensitizations demonstrated by skin-prick tests or in vitro measurement of specific IgE-antibodies are very frequent, these routine tests show a low specificity for clinically relevant allergy in patients with AE. Photopatch testing is indicated in the investigation of patients with eczematous eruptions affecting mainly light-exposed sites and in those who give a history of worsening of their condition with sun exposure. Ultraviolet A is administered to one set of allergens on the back, while a control set of allergens is not irradiated.

The article presents the summaries of papers related to dermatopathology. Basal cell carcinoma is the most common skin cancer in humans. Its development is associated with activation of the Sonic Hedgehog signalling pathway, involving the PTCH1 tumour suppressor gene and the Gli transcription factors. Currently little is known about the action of Gli proteins in mammalian cells and their role in carcinogenesis. There is an ongoing national debate on the merits or otherwise, of specialized reporting in histopathology. The researchers' hospital is a medium-sized district general hospital with five consultant histopathologists. In August 2003, the department underwent a radical redesign, moving to specialist teams with prospective division of work by specialty.

The article presents the summaries of the papers presented at the Historical Archive Symposium. The Nikolsky sign is one of the first diagnostic terms the trainee dermatologist learns for assessing a bullous disease. However, little is known about the life and work of the prominent Russian dermatologist Pyotr Vasilyevich Nikolsky himself. Nikolsky was born in 1858 in Usman in the Tambov gubernatorial region of Russia. Epidemiological studies have always played an important part in dermatology. No other disease has linked the triad of geographic distribution, genetic predisposition and prevalence more so than Behçet's disease, a chronic inflammatory disease characterized by recurrent oral and genital ulcers.

The article presents the summaries of papers related to photodermatology. Patients with systemic psoralen sensitization need to wear adequate eye protection for the day of ingestion of psoralen. A comparative assessment of the ultraviolet radiation transmission of sunglasses for patients receiving photochemotherapy. A simplified method for checking patient eyewear for suitability for systemic psoralen ultraviolet A (PUVA) uses a suitably filtered detector to measure the transmission of UVA from a hand/foot PUVA unit. However, not all units have the equipment or expertise to be able to treat patientsown glasses routinely for suitability for use after PUVA therapy.

The article presents the summaries of papers related to dermatological surgery. The reported frequencies of dermatological malignancies in Great Britain population suggests an incidence of 125 basal cell carcinomas, 27 squamous cell carcinomas and 7 malignant melanomas per 100 000. Another study reports that the number of patients attending the researchers' melanoma screening clinic since its inception in 1997 has increased fourfold. This is in contrast to the number of melanomas diagnosed, which has remained constant. During that time, 15000 patients have attended and 500 melanomas have been diagnosed; 18 melanomas have been missed.

The article presents the summaries of papers related to paediatric dermatology. Atopic dermatitis (AD) accounts for at least 15% of referrals to secondary care dermatology, often requiring multiple visits and occupying much valuable time and resources. The researchers audited the usefulness of two quality-of-life measures, the Infants Dermatitis Quality of Life index (IDQOL) and Dermatitis Family Impact (DFI), which are easy to use in a routine clinical setting. A retrospective study on allergic contact dermatitis in children was conducted in Great Britain. 503 children were identified who had undergone patch testing consecutively in the reserchers' department between the years 1995 and 2004. This represents the largest study of children who have undergone patch testing in Great Britain.

Presents summaries of several papers on dermatology. Study on the use of wet wrap in moderate atopic eczema; Hormone replacement therapy for women previously treated for malignant melanoma; Asymptomatic carriage of dermatophytes in contacts of patients with tinea capitis.

Presents summaries of several papers on photodermatology. Study of postinflammatory cutaneous hyper-reactivity syndrome; Determination of the action spectra needed to provoke erythema; Case study of xeroderma pigmentation with no skin cancer.

Summarizes research papers on dermatology, compiled as of 2002. 'Genes and environment in the expression of naevi in adults: Sunbed use is associated with high naevus counts,' by V. Bataille, P. Sasieni and others; 'Nodular melanoma: Patients' perceptions of presenting features and implications for early detection,' by A.J. Chamberlain, L. Fritschi and J.W. Kelly.

Summarizes research papers on dermatology, compiled as of 2002. 'Trial of vaccination with recombinant vaccinia virus expressing HPV 16 E6 and E7 for high grade vulval intraepithelial neoplasia,' by P. Baldwin, N. Coleman and others; 'A cost-effectiveness rationale for the selection of antimicrobial therapy in acne: A randomized controlled trial,' by M. Ozolins, E.A. Eady, A. Avery and others.

Summarizes research papers on clinico-pathological dermatologic cases, compiled as of 2002. 'Atypical erthrokeratoderma associated with a novel chromosomal translocation,' by S.A. Holme, D. Kelsel, F.R. Hinde and C. Moss; 'A silver suntan?,' by J.M.L. White, A.M. Powell, K. Brady and R. Russell-Jones; 'A new case of X-linked dominant chondrodysplasia punctata,' by S.L. Simpson-Dent, L. Izatt and others.

Summarizes research papers on contact dermatitis submitted to the British Contact Dermatitis Group, as of 2002. 'Which allergens should be in the additional series used for patch-testing?,' by C.S. Macfarlane, A.D. Morris, B. Statham, C. Green and J.S.C. English; 'House dust mite--a useful addition to the facial series,' by A.D. Morris, C.S. Macfarlane and J.S.C. English.

Summarizes research papers on dermatopathology submitted to the British Society for Dermatopathology, as of 2002. 'Analysis of dendritic cell populations in lichen sclerosis,' by J.A. Rozario, B. Jasani and others; 'Naevus or melanoma cells?,' by C.B. Muldoon and K. Blessing; 'Is malignant melanoma more common and aggressive in organ transplant recipients,' by V.L. Brown, C.A. Harwood and others.

Summarizes papers on pediatric dermatology submitted to the British Society for Pediatric Dermatology, as of 2002. 'Amastia & genitourinary abnormalities in the ectodermal dysplasia, ectrodactyly and cleft lip/palate syndrome,' by S.A. Holmes, E. Gilmour, C.M. Taylor and C. Moss; 'Herlitz junctional epidermolysis bullosa with a novel LAMB3 mutation and normal nails,' by M. Ogboli, J. McGrath and others.

Summarizes research papers on dermatology submitted to the British Photodermatology Group, as of 2002. 'Evaluation of patients who present with an exposed site dermatosis,' by I. Coutts, S. Shaw, D. Orton and S. George; 'Provocation testing in polymorphic light eruption using fluorescent ultraviolet A and UVB lamps,' by S.Das, J.J. Lloyd, D. Walshaw and P.M. Farr.

Presents the summaries of papers on clinico-pathological cases in dermatology presented during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Subcutaneous infection with Scytalidium dimidiatum; Late-onset erythropoietic protoporphyria; Paraneoplastic pemphigus associated with Castleman's tumor.

Presents the summaries of papers presented to the British Society for Dermapathology during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Sentinel lymph node sampling in malignant melanoma; Apocrine carcinoma of the skin; Deep penetrating nevus.

Relates the summaries of papers presented to the British Society for Pediatric Dermatology during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Cutaneous manifestation of congenital rubella syndrome; Buschke-Ollendorff syndrome with associated limb reduction; Childhood-onset lichen sclerosus and vulval squamous cell carcinoma.

Presents the summaries of papers on dermatology presented during the main plenary session at the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Thiopurine methyltransferase screening prior to azathioprine treatment; Treatment of Langerhans' cell histiocytosis with azathioprine; Mycophenolate mofetil in immunoglobullous disease.

Presents the summaries of papers on dermatology presented at the Registrar's Forum during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Effect of environmental exposures on genes determining variation in nevus density; Comparison between narrow-band with broadband ultraviolet B for psoriasis.

Relates the summaries of papers on photodermatology presented to the British Photodermatology Group meeting held during the 81st Annual Meeting of the British Association of Dermatologists in Cardiff, Wales on July 3-7, 2001. Guidelines for topical photodynamic therapy; Review of patients with idiopathic solar urticaria; Epidermal cell DNA damage and repai in vivo in skin cancer cases.

Lists the summaries of papers presented to the British Society for Dermatological Surgery during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Measurement of the subclinical extent of lentigo maligna; Waiting times for malignant surgery; Suspected skin malignancies in renal transplant recipients.

Presents the summaries of papers presented to the British Contact Dermatitis Group during the 81st Annual Meeting of the British Association of Dermatologists held in Cardiff, Wales on July 3-7, 2001. Evaluation of patch test data; Audit of Finn Chamber patch test preparation; Contact allergens in nurses with hand dermatitis.

Presents an abstract of the research paper 'Pruritus Vulvae–Allergic Contact Dermatitis to Textile Dyes and Toilet Roll Paper,' by I.C. Hay, A.D. Ormerod and M.I. White presented at the annual meeting of the British Contact Dermatitis Group in Great Britain.

Summary: Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory condition that can have periodic worsening or flares. Measurement of flare is important because it can inform treatment efficacy; however, it is unclear how HS flare should be defined. Objectives: This study reviewed the literature for definitions of HS flare. Methods: The PubMed MEDLINE online database was searched on 10 January 2018 and the search was repeated on 8 December 2018 for new publications. Titles and abstracts were screened for inclusion. Subsequently, full articles were screened for inclusion. Papers were included if the publication was a systematic review, clinical trial, cohort study, case report or series, or cross‐sectional study. Studies were excluded if they were journalistic reviews, did not discuss clinical findings of HS or did not use the words 'flare', 'exacerbation', 'relapse' or 'recurrence'. Results: Two hundred and seventy‐four papers were identified and 154 fulfilled the study criteria. Of these, 27 (17.5%) included the term 'flare' and 16 (10.4%) included the term 'exacerbation'. Two of the 27 papers (7%) defined the term flare and both included patient report of changes in symptoms or signs. One of 16 papers (6%) defined exacerbation, which was taken as one new HS lesion. The terms 'recurrence' and 'relapse' were more apt to be defined: 13% (13 of 100) and 14% (six of 44), respectively. Conclusions : The lack of a specific and measurable definition of HS flare is a barrier to assessment of this important outcome. Once a specific and measurable definition is established, validated and reliable measures of HS flare can be incorporated into future studies. What's already known about this topic? Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin condition.The ability to assess flares is important to people who have HS; however, it is unclear how this is defined.HS flare is one of the core outcomes in the core outcome set for HS clinical trials; however, it is unclear how this should be assessed. What does this study add? This literature review reveals the paucity of measurable definitions associated with the use of the term 'flare' in the HS literature.It also highlights the variation and lack of a validated and reliable measure of HS flare. Plain language summary available online Linked Comment: Navrazhina and Frew. Br J Dermatol 2020; 182:7. [ABSTRACT FROM AUTHOR]

Presents a subject index of various dermatological related terms published in the December 1997 issue of the "British Journal of Dermatology."

The article presents research summaries related to clinicopathological cases in Great Britain. In one of the studies, it presented a patient having deeply pigmented Eccrine porocarcinoma (EP) which occurs at a site of previous radiotherapy. Another study presents the case of patient whose diagnosis is mycosis fungoides several years after a successful treatment of chronic myeloid leukaemia. Moreover, the case of cholesterol embolization syndrome presented as lobular panniculitis is cited.

The article presents summaries related to studies in dermatology in Great Britain. Medical students from the country conducted a survey to evaluate final year medical students' experience of dermatology. Another study conducted a retrospective review on the use of azathioprine in a childhood population over an 8-year period. Furthermore, a retrospective study on all skin surgical specimens processed by the teaching hospital hispathology department for 3-month period is conducted.

The article presents summaries regarding the symposium of registrars. One of the symposiums aimed in identifying the departments concerned in the management of skin lesions, the accurateness of the clinical diagnosis, and the appropriateness of the treatment. Another is an audit which aims to look at the number of sentinel lymph node biopsy (SLNB) in the management of melanoma in Great Britain. Moreover, a retrospective analysis on toxic epidermal necrolysis is presented.

The article presents summaries regarding historical archives. The charitable organization DebRA is successful in employing administrators, fundraisers, and specialist nurses currently. On the other hand, the Psoriasis Association which is one of the pioneers in patient support and advocacy organizations around the world, turns 40 years old in 2008. Moreover, a profile on Ronald Church, a British dermatologist who has essential contributions in nosology and therapeutics is presented.

The article presents research summaries related to dermatitis in Great Britain. According to a study, it has found out that the new fungicide could be the allergen responsible for sofa dermatitis. Another study examines the use of hair dye and the frequency and nature of reported adverse reactions and the risk factors. Furthermore, a study stresses the need for education of all users of epoxy resins in regard to the skin hazard in the workplace and using proper protective equipment.