24 results on '"Ye, W."'
Search Results
2. Cancer risk in the relatives of patients with nasopharyngeal carcinoma—a register-based cohort study in Sweden
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Liu, Z, primary, Fang, F, additional, Chang, E T, additional, and Ye, W, additional
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- 2015
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3. Risk of pancreatic cancer among individuals with hepatitis C or hepatitis B virus infection: a nationwide study in Sweden
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Huang, J, primary, Magnusson, M, additional, Törner, A, additional, Ye, W, additional, and Duberg, A-S, additional
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- 2013
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4. Gastric atrophy and oesophageal squamous cell carcinoma: possible interaction with dental health and oral hygiene habit
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Nasrollahzadeh, D, primary, Malekzadeh, R, additional, Aghcheli, K, additional, Sotoudeh, M, additional, Merat, S, additional, Islami, F, additional, Kamangar, F, additional, Abnet, C C, additional, Shakeri, R, additional, Pourshams, A, additional, Semnani, S, additional, Boffetta, P, additional, Dawsey, S M, additional, and Ye, W, additional
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- 2012
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5. Inflammation marker and risk of pancreatic cancer: a nested case–control study within the EPIC cohort
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Grote, V A, primary, Kaaks, R, additional, Nieters, A, additional, Tjønneland, A, additional, Halkjær, J, additional, Overvad, K, additional, Skjelbo Nielsen, M R, additional, Boutron-Ruault, M C, additional, Clavel-Chapelon, F, additional, Racine, A, additional, Teucher, B, additional, Becker, S, additional, Pischon, T, additional, Boeing, H, additional, Trichopoulou, A, additional, Cassapa, C, additional, Stratigakou, V, additional, Palli, D, additional, Krogh, V, additional, Tumino, R, additional, Vineis, P, additional, Panico, S, additional, Rodríguez, L, additional, Duell, E J, additional, Sánchez, M-J, additional, Dorronsoro, M, additional, Navarro, C, additional, Gurrea, A B, additional, Siersema, P D, additional, HM Peeters, P, additional, Ye, W, additional, Sund, M, additional, Lindkvist, B, additional, Johansen, D, additional, Khaw, K-T, additional, Wareham, N, additional, Allen, N E, additional, Travis, R C, additional, Fedirko, V, additional, Jenab, M, additional, Michaud, D S, additional, Chuang, S-C, additional, Romaguera, D, additional, Bueno-de-Mesquita, H B, additional, and Rohrmann, S, additional
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- 2012
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6. Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
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Rohrmann, S, primary, Grote, V A, additional, Becker, S, additional, Rinaldi, S, additional, Tjønneland, A, additional, Roswall, N, additional, Grønbæk, H, additional, Overvad, K, additional, Boutron-Ruault, M C, additional, Clavel-Chapelon, F, additional, Racine, A, additional, Teucher, B, additional, Boeing, H, additional, Drogan, D, additional, Dilis, V, additional, Lagiou, P, additional, Trichopoulou, A, additional, Palli, D, additional, Tagliabue, G, additional, Tumino, R, additional, Vineis, P, additional, Mattiello, A, additional, Rodríguez, L, additional, Duell, E J, additional, Molina-Montes, E, additional, Dorronsoro, M, additional, Huerta, J-M, additional, Ardanaz, E, additional, Jeurnink, S, additional, Peeters, P H M, additional, Lindkvist, B, additional, Johansen, D, additional, Sund, M, additional, Ye, W, additional, Khaw, K-T, additional, Wareham, N J, additional, Allen, N E, additional, Crowe, F L, additional, Fedirko, V, additional, Jenab, M, additional, Michaud, D S, additional, Norat, T, additional, Riboli, E, additional, Bueno-de-Mesquita, H B, additional, and Kaaks, R, additional
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- 2012
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7. Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort
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Abnet, C C, primary, Zheng, W, additional, Ye, W, additional, Kamangar, F, additional, Ji, B-T, additional, Persson, C, additional, Yang, G, additional, Li, H-L, additional, Rothman, N, additional, Shu, X-O, additional, Gao, Y-T, additional, and Chow, W-H, additional
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- 2011
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8. Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran
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Nasrollahzadeh, D, primary, Kamangar, F, additional, Aghcheli, K, additional, Sotoudeh, M, additional, Islami, F, additional, Abnet, C C, additional, Shakeri, R, additional, Pourshams, A, additional, Marjani, H A, additional, Nouraie, M, additional, Khatibian, M, additional, Semnani, S, additional, Ye, W, additional, Boffetta, P, additional, Dawsey, S M, additional, and Malekzadeh, R, additional
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- 2008
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9. Parity and risk of stomach cancer by sub-site: a national Swedish study
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Bahmanyar, S, primary, Lambe, M, additional, Zendehdel, K, additional, Nyrén, O, additional, Boffetta, P, additional, and Ye, W, additional
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- 2008
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10. Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden
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Chandanos, E, primary, Lindblad, M, additional, Jia, C, additional, Rubio, C A, additional, Ye, W, additional, and Lagergren, J, additional
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- 2006
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11. No excess risk of colorectal cancer among alcoholics followed for up to 25 years
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Ye, W, primary, Romelsjö, A, additional, Augustsson, K, additional, Adami, H-O, additional, and Nyrén, O, additional
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- 2003
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12. Risk of adenocarcinomas of the oesophagus and gastric cardia in patients hospitalized for asthma
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Ye, W, primary, Chow, W-H, additional, Lagergren, J, additional, Boffetta, P, additional, Boman, G, additional, Adami, H-O, additional, and Nyrén, O, additional
- Published
- 2001
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13. Risk of cancers of the lung, head and neck in patients hospitalized for alcoholism in Sweden
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Boffetta, P, primary, Ye, W, additional, Adami, H-O, additional, Mucci, L A, additional, and Nyrén, O, additional
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- 2001
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14. Alcohol and breast cancer risk: the alcoholism paradox
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Kuper, H, primary, Ye, W, additional, Weiderpass, E, additional, Ekbom, A, additional, Trichopoulos, D, additional, Nyrén, O, additional, and Adami, H-O, additional
- Published
- 2000
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15. Gastric atrophy and oesophageal squamous cell carcinoma: possible interaction with dental health and oral hygiene habit
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Sanford M. Dawsey, Shahin Merat, Reza Malekzadeh, Farhad Islami, Dariush Nasrollahzadeh, Shahryar Semnani, Akram Pourshams, Karim Aghcheli, M Sotoudeh, Paolo Boffetta, Farin Kamangar, Christian C. Abnet, Ramin Shakeri, Weimin Ye, Nasrollahzadeh, D., Malekzadeh, R., Aghcheli, K., Sotoudeh, M., Merat, S., Islami, F., Kamangar, F., Abnet, C.C., Shakeri, R., Pourshams, A., Semnani, S., Boffetta, P., Dawsey, S.M., and Ye, W.
- Subjects
Gastritis, Atrophic ,Male ,Cancer Research ,medicine.medical_specialty ,Esophageal Neoplasms ,Epidemiology ,Gastroenterology ,Oral hygiene ,Atrophy ,Risk Factors ,Pepsinogen A ,Surveys and Questionnaires ,atrophic gastritis ,Internal medicine ,Pepsinogen C ,medicine ,Humans ,dental health ,oesophageal neoplasm ,pepsinogen ,Risk factor ,business.industry ,Confounding ,Case-control study ,Absolute risk reduction ,oral hygiene ,Odds ratio ,Middle Aged ,oesophageal squamous cell carcinoma OSCC ,medicine.disease ,Confidence interval ,poor dental health and oral hygiene habit ,relative risk ,stomatognathic diseases ,Gastric atrophy ,Oncology ,Case-Control Studies ,Carcinoma, Squamous Cell ,Female ,business - Abstract
Background:Gastric fundal atrophy has been hypothesised to increase the risk of oesophageal squamous cell carcinoma (OSCC), but studies have shown inconsistent results.Methods:We measured serum pepsinogen I (PGI) and pepsinogen II (PGII) among 293 incident cases and 524 matched neighbourhood controls in a high-risk area of Northern Iran. Conditional logistic regression model was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs).Results:After controlling for age, sex, residence area and other potential confounders, gastric atrophy (defined by a validated criterion, PGI
- Published
- 2012
16. Inflammation marker and risk of pancreatic cancer: a nested case–control study within the EPIC cohort
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Petra H.M. Peeters, C. Navarro, Birgit Teucher, M. C. Boutron-Ruault, Rudolf Kaaks, Kim Overvad, Ruth C. Travis, Antoine Racine, Susen Becker, Heiner Boeing, Dora Romaguera, Rosario Tumino, Nicholas J. Wareham, M. R. Skjelbo Nielsen, Eric J. Duell, V. Stratigakou, Anne Tjønneland, Malin Sund, Björn Lindkvist, H. B. Bueno-de-Mesquita, Salvatore Panico, K. T. Khaw, F. Clavel-Chapelon, Jytte Halkjær, Sabine Rohrmann, C. Cassapa, V. A. Grote, Vittorio Krogh, Shu Chun Chuang, Peter D. Siersema, Naomi E. Allen, Aurelio Barricarte Gurrea, Paolo Vineis, M. Dorronsoro, L. Rodríguez, Weimin Ye, Domenico Palli, María José Sánchez, Veronika Fedirko, Antonia Trichopoulou, Dorthe Johansen, Dominique S. Michaud, Mazda Jenab, Alexandra Nieters, Tobias Pischon, University of Zurich, Kaaks, R, Grote, Va, Nieters, A, Tj?nneland, A, Halkj?r, J, Overvad, K, Skjelbo Nielsen, Mr, Boutron Ruault, Mc, Clavel Chapelon, F, Racine, A, Teucher, B, Becker, S, Pischon, T, Boeing, H, Trichopoulou, A, Cassapa, C, Stratigakou, V, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, Salvatore, Rodr?guez, L, Duell, Ej, S?nchez, Mj, Dorronsoro, M, Navarro, C, Gurrea, Ab, Siersema, Pd, Peeters, Ph, Ye, W, Sund, M, Lindkvist, B, Johansen, D, Khaw, Kt, Wareham, N, Allen, Ne, Travis, Rc, Fedirko, V, Jenab, M, Michaud, D, Chuang, Sc, Romaguera, D, Bueno de Mesquita, Hb, and Rohrmann, S.
- Subjects
Oncology ,Male ,Cancer Research ,Epidemiology ,pancreatic cancer ,Receptors, Tumor Necrosis Factor ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,1306 Cancer Research ,0303 health sciences ,biology ,food and beverages ,Middle Aged ,3. Good health ,C-Reactive Protein ,030220 oncology & carcinogenesis ,Cohort ,2730 Oncology ,Female ,CRP ,Cohort study ,Adult ,medicine.medical_specialty ,610 Medicine & health ,03 medical and health sciences ,Diabetes mellitus ,Pancreatic cancer ,Internal medicine ,medicine ,Biomarkers, Tumor ,Humans ,030304 developmental biology ,Aged ,Inflammation ,IL-6 ,business.industry ,TNF receptor ,Interleukin-6 ,C-reactive protein ,Case-control study ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,medicine.disease ,Pancreatic Neoplasms ,Endocrinology ,Case-Control Studies ,Nested case-control study ,biology.protein ,Pancreatitis ,business ,EPIC - Abstract
BACKGROUND: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-α (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. RESULTS: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR=1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR=1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. CONCLUSION: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer.
- Published
- 2012
17. Opium, tobacco, and alcohol use in relation to oesophageal squamous cell carcinoma in a high-risk area of Iran
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Christian C. Abnet, Akram Pourshams, K Aghcheli, Sanford M. Dawsey, Mehdi Nouraie, Masoud Sotoudeh, Shahryar Semnani, Morteza Khatibian, Ramin Shakeri, Reza Malekzadeh, Farin Kamangar, Paolo Boffetta, Weimin Ye, D Nasrollahzadeh, Farhad Islami, H A Marjani, Nasrollahzadeh, D., Kamangar, F., Aghcheli, K., Sotoudeh, M., Islami, F., Abnet, C.C., Shakeri, R., Pourshams, A., Marjani, H.A., Nouraie, M., Khatibian, M., Semnani, S., Ye, W., Boffetta, P., Dawsey, S.M., and Malekzadeh, R.
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Adult ,Male ,oesophageal cancer ,Cancer Research ,medicine.medical_specialty ,Alcohol Drinking ,Esophageal Neoplasms ,Epidemiology ,Alcohol ,Iran ,Opium ,tobacco ,chemistry.chemical_compound ,Risk area ,Risk Factors ,Internal medicine ,medicine ,Humans ,Basal cell ,Letters to the Editor ,Aged ,alcohol ,business.industry ,Smoking ,Confounding ,Cancer ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,oesophageal squamous cell carcinoma ,Oncology ,chemistry ,Carcinoma, Squamous Cell ,Female ,business ,Mutagens ,medicine.drug - Abstract
The very high incidence of oesophageal squamous cell carcinoma (ESCC) in Golestan Province in northeastern Iran was suggested by studies in the 1970s as partly due to opium use, which is not uncommon in this area, but based on limited numbers. From December 2003 to June 2007, we administered a validated structured questionnaire to 300 ESCC cases and 571 controls, matched on neighbourhood of residence, age (±2 years), and sex. We used conditional logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for potential confounders. Compared with those who used neither tobacco nor opium, risk of ESCC was increased in those who used tobacco only (OR, 95% CI: 1.70, 1.05-2.73), in those who used opium only (2.12, 1.21-3.74), and in those who used both tobacco and opium (2.35, 1.50-3.67). All forms of tobacco use (cigarettes, hookah, and nass) were associated with higher ESCC risk. Similarly, use of both crude opium and other forms of opium were associated with higher risk. Alcohol consumption was seen in only 2% of the cases and 2% of the controls, and was not associated with ESCC risk. © 2008 Cancer Research.
- Published
- 2008
18. Parity and risk of stomach cancer by sub-site: a national Swedish study
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Weimin Ye, Mats Lambe, Olof Nyrén, Shahram Bahmanyar, Kazem Zendehdel, Paolo Boffetta, Bahmanyar, S., Lambe, M., Zendehdel, K., Nyrén, O., Boffetta, P., and Ye, W.
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Adult ,Risk ,Cancer Research ,medicine.medical_specialty ,Epidemiology ,nested case – control study ,Pregnancy ,Stomach Neoplasms ,medicine ,Odds Ratio ,Humans ,Risk factor ,Stomach cancer ,Aged ,Gynecology ,Sweden ,stomach cancer ,Obstetrics ,business.industry ,Case-control study ,Cancer ,Cardia ,Odds ratio ,nested case–control study ,Middle Aged ,medicine.disease ,Parity ,Oncology ,Case-Control Studies ,Nested case-control study ,Cohort ,Female ,business ,Parity (mathematics) - Abstract
We investigated stomach cancer risk by anatomic sub-site in relation to parity, as a marker for higher exposure to sex hormones, in a case-control study, nested within a cohort of 2 406 439 Swedish women born in 1925 or later and followed from 1970 or age 30 until emigration, death, any cancer diagnosis, or through 2004, whichever occurred first. We identified 286 cardia and 2498 non-cardia stomach cancer cases with five matched controls for each case. Cross-linkage with the Multi-Generation Register provided information about reproductive history. Using conditional logistic regression models for estimating odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for education level and occupation, we found no association between any aspect of parity and non-cardia stomach cancer (OR=1.01, 95% CI 0.89-1.15, comparing parous with nulliparous women). However, a 30% risk reduction for postmenopausal cardia cancer (OR=0.7, 95% CI 0.4-1.0) was noted among parous relative to nulliparous women and the risk for premenopausal cardia cancer fell with increasing number of children (P for trend=0.04). Our results indicate that exposure to female sex hormones does not protect against non-cardia stomach cancer and does not explain male predominance. The observed moderate inverse relationship between parity and cardia cancer may be mediated by non-hormonal factors and warrants further study. © 2008 Cancer Research.
- Published
- 2008
19. Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers.
- Author
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Xu H, Bretthauer M, Fang F, Ye W, Yin L, and Adami HO
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- Humans, Male, Female, Aged, Middle Aged, Sweden epidemiology, Treatment Outcome, Common Bile Duct Neoplasms surgery, Common Bile Duct Neoplasms mortality, Common Bile Duct Neoplasms pathology, Aged, 80 and over, Adult, Bile Duct Neoplasms surgery, Bile Duct Neoplasms mortality, Pancreaticoduodenectomy methods, Pancreaticoduodenectomy mortality, Pancreatic Neoplasms surgery, Pancreatic Neoplasms mortality, Ampulla of Vater surgery, Ampulla of Vater pathology, Duodenal Neoplasms surgery, Duodenal Neoplasms mortality, Duodenal Neoplasms pathology
- Abstract
Background: Pancreatoduodenectomy is the only cure for cancers of the pancreas and the periampullary region but has considerable operative complications and uncertain prognosis. Our goal was to analyse temporal improvements and provide contemporary population-based benchmarks for outcomes following pancreatoduodenectomy., Methods: We empanelled a cohort comprising all patients in Sweden with pancreatic or periampullary cancer treated with pancreatoduodenectomy from 1964 to 2016 and achieved complete follow-up through 2016. We analysed postoperative deaths and disease-specific net survival., Results: We analysed 5923 patients with cancer of the pancreas (3876), duodenum (444), bile duct (504), or duodenal papilla (963) who underwent classic (3332) or modified (1652) Whipple's procedure or total pancreatectomy (803). Postoperative deaths declined from 17.2% in the 1960s to 1.6% in the contemporary time period (2010-2016). For all four cancer types, median, 1-year and 5-year survival improved substantially over time. Among patients operated between 2010 and 2016, 5-year survival was 29.0% (95% confidence interval (CI): 25.5, 33.0) for pancreatic cancer, 71.2% (95% CI: 62.9, 80.5) for duodenal cancer, 30.8% (95% CI: 23.0, 41.3) for bile duct cancer, and 62.7% (95% CI: 55.5, 70.8) for duodenal papilla cancer., Conclusion: There is a continuous and substantial improvement in the benefit-harm ratio after pancreatoduodenectomy for cancer., (© 2024. The Author(s).)
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- 2024
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20. HLA-A + tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma.
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Zhang D, Jiang D, Jiang L, Ma J, Wang X, Xu X, Chen Z, Jiang M, Ye W, Wang J, Meng W, Qiu W, Hou Y, Huang J, Jiao Y, Liu Y, and Liu Z
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- Humans, Female, Male, Immune Checkpoint Inhibitors therapeutic use, Immune Checkpoint Inhibitors pharmacology, Middle Aged, Aged, Biomarkers, Tumor metabolism, Lymphocytes, Tumor-Infiltrating immunology, Esophageal Squamous Cell Carcinoma immunology, Esophageal Squamous Cell Carcinoma pathology, Esophageal Squamous Cell Carcinoma therapy, Esophageal Squamous Cell Carcinoma genetics, Tertiary Lymphoid Structures immunology, Tertiary Lymphoid Structures pathology, Esophageal Neoplasms immunology, Esophageal Neoplasms pathology, Esophageal Neoplasms therapy, Esophageal Neoplasms drug therapy, Esophageal Neoplasms genetics, Immunotherapy methods, Tumor Microenvironment immunology, HLA-A Antigens immunology, HLA-A Antigens genetics
- Abstract
Background: Immune checkpoint blockade (ICB) therapy provides remarkable clinical benefits for multiple cancer types. However, the overall response rate to ICB therapy remains low in esophageal squamous cell carcinoma (ESCC). This study aimed to identify biomarkers of ICB therapy for ESCC and interrogate its potential clinical relevance., Methods: We investigated gene expression in 42 treatment-naïve ESCC tumor tissues and identified differentially expressed genes, tumor-infiltrating lymphocytes and immune-related genes signatures associated with differential immunotherapy responses. We systematically assessed the tumor microenvironment using the NanoString GeoMx digital spatial profiler, single-cell RNA-seq and multiplex immunohistochemistry in ESCC. Finally, we evaluated the associations between HLA-A-positive tertiary lymphoid structures (TLSs) and patients' responses to ICB in 60 ESCC patients., Results: Tumor infiltrating B lymphocytes and several immune-related gene signatures, such as the antigen presenting machinery (APM) signature, are significantly elevated in ICB treatment responders. Multiplex immunohistochemistry identified the presence of HLA-A
+ TLSs and showed that TLS-resident cells increasingly express HLA-A as TLSs mature. Most TLS-resident HLA-A+ cells are tumor-infiltrating T (TIL-T) or tumor-infiltrating B (TIL-B) lymphocytes. Digital spatial profiling of spatially distinct TIL-T lymphocytes and single-cell RNA-seq data from 60 ESCC tumor tissues revealed that CXCL13-expressing exhausted TIL-Ts inside TLSs are reactivated with elevated expression of the APM signature as TLSs mature. Finally, we demonstrated that HLA-A+ TLSs and their major cellular components, TIL-Ts and TIL-Bs, are associated with a clinical benefit from ICB treatment for ESCC., Conclusions: HLA-A+ TLSs are present in ESCC tumor tissues. TLS-resident TIL-Ts with elevated expression of the APM signature may be reactivated. HLA-A+ TLSs and their major cellular components, TIL-Ts and TIL-Bs, may serve as biomarkers for ICB-treated ESCC patients., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)- Published
- 2024
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21. Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016.
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Yu J, Ploner A, Chen MS, Zhang J, Sandborgh-Englund G, and Ye W
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- Humans, Cohort Studies, Sweden epidemiology, Dental Caries epidemiology, Pancreatic Neoplasms epidemiology
- Abstract
Background: Previous studies have reported inconsistent results regarding the association between poor dental health and pancreatic cancer risk. This study aimed to assess this association using a well-functioning nationwide dental health registry in Sweden., Methods: Information of exposures (dental caries, root canal infection, mild inflammation, and periodontitis; the number of teeth) was ascertained from the Swedish Dental Health Register, and occurrence of pancreatic cancer was identified from both cancer and cause of death registries. Hazard ratios (HRs) were estimated using Cox models., Results: During a median of 7.2 years of follow-up, 10,081 pancreatic cancers were identified among 5,889,441 individuals. Compared with the healthy status, a higher risk of pancreatic cancer was observed in individuals with root canal infection, mild inflammation, and periodontitis in the <50 age group (P for trend <0.001). In the 50-70 age group, only the subgroup with periodontitis had an excess risk (multivariable-adjusted HR = 1.20, 95% confidence interval [CI] 1.11-1.29). No positive association with statistical significance was observed in the 70+ age group. Individuals with fewer teeth tended to have a higher risk in all age groups., Conclusions: Our results confirmed the association between poor dental health and pancreatic cancer risk, which warrants further studies on underlying mechanisms., (© 2022. The Author(s).)
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- 2022
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22. Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles.
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Ye W, Olsson-Brown A, Watson RA, Cheung VTF, Morgan RD, Nassiri I, Cooper R, Taylor CA, Akbani U, Brain O, Matin RN, Coupe N, Middleton MR, Coles M, Sacco JJ, Payne MJ, and Fairfax BP
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Agents, Immunological adverse effects, Antineoplastic Agents, Immunological therapeutic use, Autoimmune Diseases diagnosis, Autoimmune Diseases epidemiology, Autoimmune Diseases genetics, Autoimmunity drug effects, Autoimmunity genetics, CD8-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes pathology, Female, Gene Expression Regulation, Neoplastic drug effects, Humans, Immune Checkpoint Inhibitors therapeutic use, Immunotherapy adverse effects, Male, Melanoma immunology, Melanoma mortality, Melanoma pathology, Middle Aged, Neoplasm Metastasis, Prognosis, Progression-Free Survival, Retrospective Studies, Skin Neoplasms drug therapy, Skin Neoplasms immunology, Skin Neoplasms mortality, Skin Neoplasms pathology, Survival Analysis, Transcriptome drug effects, Transcriptome immunology, Treatment Outcome, United Kingdom epidemiology, Autoimmune Diseases chemically induced, CD8-Positive T-Lymphocytes drug effects, Immune Checkpoint Inhibitors adverse effects, Melanoma drug therapy
- Abstract
Background: Immune checkpoint blockers (ICBs) activate CD8
+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear., Methods: Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab-sICB) or combination (nivolumab and ipilimumab-cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed., Results: 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9-33.4) versus not-reached (P = 2.8 × 10-6 ). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment., Conclusions: Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.- Published
- 2021
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23. Body mass index change during adulthood and risk of oesophageal squamous-cell carcinoma in a Japanese population: the Japan Public Health (JPHC)-based prospective study.
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Song H, Saito E, Sawada N, Abe SK, Hidaka A, Shimazu T, Yamaji T, Goto A, Iwasaki M, Sasazuki S, Ye W, Inoue M, and Tsugane S
- Subjects
- Adult, Aged, Esophageal Squamous Cell Carcinoma, Female, Humans, Male, Middle Aged, Prospective Studies, Public Health, Risk, Body Mass Index, Carcinoma, Squamous Cell etiology, Esophageal Neoplasms etiology
- Abstract
Background: The influence of body mass index (BMI) change during adulthood on the development of oesophageal squamous-cell carcinoma (ESCC) is unknown., Methods: Based on the Japan Public Health Center-based Prospective Study, we enrolled 103 238 participants from 1990 to 1994. Anthropometric data at age 20 years, baseline, and 5- and/or 10-year follow-up surveys were collected by questionnaire. The effect of BMI change between age 20 years and baseline on ESCC risk was estimated by Cox proportional hazards regression models. The updated BMI was taken into account by fitting a simple linear regression model for each individual, where the slope was incorporated into regressions as a time-varying variable., Results: After excluding the first 5 years of observation, we identified 342 newly diagnosed ESCC cases. An increase in BMI during adulthood was linked with a decreased risk of ESCC development, with each 1% increase per 5 years corresponding to a 15% decrease in ESCC risk (95% confidence interval 9-21%). Identical estimates were obtained from time-dependent models. The importance of BMI change was not modified by gender, smoking, or alcohol drinking but confined to participants assessed as non-overweight at baseline., Conclusions: An increase in BMI during adulthood is associated with a lower risk of developing ESCC among non-overweight subjects.
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- 2017
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24. Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort.
- Author
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Molina-Montes E, Sánchez MJ, Buckland G, Bueno-de-Mesquita HB, Weiderpass E, Amiano P, Wark PA, Kühn T, Katzke V, Huerta JM, Ardanaz E, Quirós JR, Affret A, His M, Boutron-Ruault MC, Peeters PH, Ye W, Sund M, Boeing H, Iqbal K, Ohlsson B, Sonestedt E, Tjønneland A, Petersen KE, Travis RC, Skeie G, Agnoli C, Panico S, Palli D, Tumino R, Sacerdote C, Freisling H, Huybrechts I, Overvad K, Trichopoulou A, Bamia C, Vasilopoulou E, Wareham N, Khaw KT, Cross AJ, Ward HA, Riboli E, and Duell EJ
- Subjects
- Female, Follow-Up Studies, Humans, Life Style, Male, Middle Aged, Neoplasm Staging, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Factors, Surveys and Questionnaires, White People, Diet, Mediterranean, Nutrition Assessment, Pancreatic Neoplasms prevention & control
- Abstract
Background: The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort., Methods: Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs)., Results: Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern., Conclusions: A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.
- Published
- 2017
- Full Text
- View/download PDF
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