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Your search keyword '"Rita E. Weathers"' showing total 2 results
Start Over Author "Rita E. Weathers" Journal british journal of cancer
2 results on '"Rita E. Weathers"'

1. Increased pancreatic cancer risk following radiotherapy for testicular cancer

Author

Sophie D. Fosså, Eric J. Holowaty, Charles F. Lynch, Michael Andersson, Tom Børge Johannesen, Alexandra W. van den Belt-Dusebout, Joseph F. Fraumeni, Hans H. Storm, Flora E. van Leeuwen, Michael Hauptmann, Marilyn Stovall, Rita E. Weathers, Magnus Kaijser, Lindsay M. Morton, Ethel S. Gilbert, Per Hall, Lois B. Travis, Heikki Joensuu, Eero Pukkala, Berthe M.P. Aleman, Ruth A. Kleinerman, Rochelle E. Curtis, Preetha Rajaraman, Leila Vaalavirta, Susan A. Smith, Frøydis Langmark, and Graça M. Dores

Subjects
Male, Organs at Risk, 0301 basic medicine, Oncology, Cancer Research, Neoplasms, Radiation-Induced, Epidemiology, medicine.medical_treatment, pancreatic cancer, chemotherapy, 0302 clinical medicine, Cumulative incidence, Young adult, Neoplasms, Second Primary, Radiotherapy Dosage, Middle Aged, Combined Modality Therapy, testicular cancer, 3. Good health, medicine.anatomical_structure, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Pancreas, Adult, Risk, medicine.medical_specialty, Young Adult, 03 medical and health sciences, Testicular Neoplasms, Pancreatic cancer, Internal medicine, medicine, Humans, radiotherapy, Testicular cancer, Aged, Chemotherapy, business.industry, logistic regression, Dose-Response Relationship, Radiation, Odds ratio, medicine.disease, Pancreatic Neoplasms, Radiation therapy, 030104 developmental biology, Case-Control Studies, business, Orchiectomy
Abstract

Background: Pancreatic cancer risk is elevated among testicular cancer (TC) survivors. However, the roles of specific treatments are unclear. Methods: Among 23 982 5-year TC survivors diagnosed during 1947–1991, doses from radiotherapy to the pancreas were estimated for 80 pancreatic cancer patients and 145 matched controls. Chemotherapy details were recorded. Logistic regression was used to estimate odds ratios (ORs). Results: Cumulative incidence of second primary pancreatic cancer was 1.1% at 30 years after TC diagnosis. Radiotherapy (72 (90%) cases and 115 (80%) controls) was associated with a 2.9-fold (95% confidence interval (CI) 1.0–7.8) increased risk. The OR increased linearly by 0.12 per Gy to the pancreas (P-trend

Published
2016

2. Increased stomach cancer risk following radiotherapy for testicular cancer

Author

Charles F. Lynch, Rita E. Weathers, Preetha Rajaraman, Leila Vaalavirta, J. F. Fraumeni, S. A. Smith, Eric J. Holowaty, Lindsay M. Morton, Frøydis Langmark, Berthe M.P. Aleman, Eero Pukkala, Hans H. Storm, Sophie D. Fosså, Rochelle E. Curtis, Lois B. Travis, Graça M. Dores, Magnus Kaijser, Heikki Joensuu, Marilyn Stovall, Michael Andersson, A.W. van den Belt-Dusebout, Ruth A. Kleinerman, F.E. van Leeuwen, Per Hall, Ethel S. Gilbert, Michael Hauptmann, and Tom Børge Johannesen

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Neoplasms, Radiation-Induced, Adolescent, medicine.medical_treatment, chemotherapy, Gastroenterology, Cohort Studies, Young Adult, Testicular Neoplasms, Stomach Neoplasms, Internal medicine, medicine, Humans, Cumulative incidence, Survivors, Stomach cancer, Testicular cancer, radiotherapy, Aged, stomach cancer, business.industry, Stomach, Incidence (epidemiology), Incidence, Case-control study, Dose-Response Relationship, Radiation, Radiotherapy Dosage, Odds ratio, Middle Aged, medicine.disease, 3. Good health, Surgery, testicular cancer, Radiation therapy, medicine.anatomical_structure, Oncology, Case-Control Studies, Clinical Study, Female, business
Abstract

Background: Abdominal radiotherapy for testicular cancer (TC) increases risk for second stomach cancer, although data on the radiation dose–response relationship are sparse. Methods: In a cohort of 22 269 5-year TC survivors diagnosed during 1959–1987, doses to stomach subsites were estimated for 92 patients who developed stomach cancer and 180 matched controls. Chemotherapy details were recorded. Odds ratios (ORs) were estimated using logistic regression. Results: Cumulative incidence of second primary stomach cancer was 1.45% at 30 years after TC diagnosis. The TC survivors who received radiotherapy (87 (95%) cases, 151 (84%) controls) had a 5.9-fold (95% confidence interval (CI) 1.7–20.7) increased risk of stomach cancer. Risk increased with increasing stomach dose (P-trend

Published
2014

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