1. The etiology of uterine sarcomas: a pooled analysis of the epidemiology of endometrial cancer consortium
- Author
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X. Ou Shu, Lauren A. Wise, L N Kolonel, Pamela L. Horn-Ross, Ashley S. Felix, Kim Robien, Hannah P. Yang, Lynn Rosenberg, B. E. Henderson, I. De Vivo, Leo J. Schouten, Catherine Schairer, Anthony M. Magliocco, Yikyung Park, Xiaowen Liang, Wanghong Xu, Christine M. Friedenreich, Marjorie L. McCullough, L A Brinton, Mia M. Gaudet, Julie R. Palmer, Leslie Bernstein, N. Wentzensen, James V. Lacey, T E Rohan, Veronica Wendy Setiawan, Jolanta Lissowska, R.A. Goldbohm, Anthony B. Miller, Susan M. Gapstur, Radhai Rastogi, Linda S. Cook, Alpa V. Patel, Sara H. Olson, P.A. van den Brandt, Kristin E. Anderson, R. A. Virkus, Yong-Bing Xiang, Jennifer Prescott, Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, and RS: GROW - School for Oncology and Reproduction
- Subjects
Cancer Research ,medicine.medical_specialty ,obesity ,uterine sarcoma ,Epidemiology ,Mixed Tumor, Mullerian ,LS - Life Style ,Body Mass Index ,Risk Factors ,Medicine ,Humans ,Risk factor ,Uterine Neoplasm ,Aged ,Gynecology ,Uterine sarcoma ,diabetes ,business.industry ,Endometrial cancer ,Incidence (epidemiology) ,Incidence ,Case-control study ,Sarcoma ,Odds ratio ,Middle Aged ,medicine.disease ,Prognosis ,BSS - Behavioural and Societal Sciences ,United States ,Endometrial Neoplasms ,Oncology ,Health ,Case-Control Studies ,Uterine Neoplasms ,Female ,Healthy for Life ,pooled analysis ,business ,Healthy Living ,Human ,Follow-Up Studies - Abstract
Background: Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their aetiology is poorly understood. Therefore, we performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined risk factor associations for malignant mixed mullerian tumours (MMMTs) and endometrioid endometrial carcinomas (EECs) for comparison purposes. Methods: We pooled data on 229 uterine sarcomas, 244 MMMTs, 7623 EEC cases, and 28 829 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for risk factors associated with uterine sarcoma, MMMT, and EEC were estimated with polytomous logistic regression. We also examined associations between epidemiological factors and histological subtypes of uterine sarcoma. Results: Significant risk factors for uterine sarcoma included obesity (body mass index (BMI)≥30 vs BMI
- Published
- 2013