1. A web-based prognostic tool for extremity and trunk wall soft tissue sarcomas and its external validation
- Author
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Mika Sampo, Pentscho Popov, Johan Lundin, Carl Blomqvist, Erkki Tukiainen, Pelle Gustafson, Mikael Lundin, Tom Böhling, and Maija Tarkkanen
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,web-based ,Soft Tissue Neoplasms ,Kaplan-Meier Estimate ,chemotherapy ,Online Systems ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,030212 general & internal medicine ,Aged ,Proportional Hazards Models ,Aged, 80 and over ,business.industry ,Proportional hazards model ,Trunk wall ,Soft tissue sarcoma ,External validation ,Soft tissue ,Sarcoma ,Middle Aged ,Prognosis ,medicine.disease ,Tumor Burden ,3. Good health ,Surgery ,ROC Curve ,Oncology ,soft tissue sarcoma ,Area Under Curve ,030220 oncology & carcinogenesis ,Calibration ,Multivariate Analysis ,Clinical Study ,Female ,Neoplasm Grading ,business ,Nuclear medicine ,Area under the roc curve - Abstract
BACKGROUND: We developed a web-based, prognostic tool for extremity and trunk wall soft tissue sarcoma to predict 10-year sarcoma-specific survival. External validation was performed. METHODS: Patients referred during 1987-2002 to Helsinki University Central Hospital are included. External validation was obtained from the Lund University Hospital register. Cox proportional hazards models were fitted with the Helsinki data. The previously described model (SIN) includes size, necrosis, and vascular invasion. The extended model (SAM) includes the SIN factors and in addition depth, location, grade, and size on a continuous scale. Models were statistically compared according to accuracy (area under the ROC curve = AUC) of 10-year sarcoma-specific survival prediction. RESULTS: The AUC of the SAM model in 10-year survival prediction in the Helsinki patient series was 0.81 as compared with 0.74 for the SIN model (P = 0.0007). The corresponding AUCs in the external validation series were 0.77 for the SAM model and 0.73 for the SIN model (P = 0.03). A web-based calculator for the SAM model is available at http://www.prognomics.org/sam. CONCLUSION: Addition of grade, depth, and location as well as tumour size on a continuous scale significantly improved the accuracy of the prognostic model when compared with a model that includes only size, necrosis, and vascular invasion. British Journal of Cancer (2012) 106, 1076-1082. doi:10.1038/bjc.2012.48 www.bjcancer.com Published online 21 February 2012 (C) 2012 Cancer Research UK
- Published
- 2012