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Start Over Author "J. Gudmundsson" Journal british journal of cancer
3 results on '"J. Gudmundsson"'

1. European multicenter study on LOH of APOC3 at 11q23 in 766 breast cancer patients: relation to clinical variables. Breast Cancer Somatic Genetics Consortium

Author

V, Launonen, K, Laake, P, Huusko, D, Niederacher, M W, Beckmann, R B, Barkardottir, E K, Geirsdottir, J, Gudmundsson, P, Rio, Y J, Bignon, S, Seitz, S, Scherneck, I, Bièche, M H, Champème, D, Birnbaum, G, White, J, Varley, M, Sztán, E, Olah, A, Osorio, J, Benitez, N, Spurr, N, Velikonja, B, Peterlin, and R, Winqvist

Subjects
Adult, Aged, 80 and over, Genetic Markers, Chromosomes, Human, Pair 11, Loss of Heterozygosity, Breast Neoplasms, Regular Article, Middle Aged, Europe, breast cancer, chromosome 11q23, Humans, Female, Apolipoproteins C, Aged
Abstract

High frequencies of loss of heterozygosity (LOH) in chromosome 11q22-qter have been observed in various malignancies, including breast cancer. Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660–2664) have indicated that a survival factor gene is located in band 11q23, and that the highly informative microsatellite polymorphism at the APOC3 locus would be a suitable tool to perform more extensive LOH studies. In this European multicentre study, we have examined the occurrence of APOC3 LOH and evaluated the effect of LOH of this chromosomal subregion on the clinical behaviour of the disease in a cohort of 766 breast cancer patients in more detail. LOH for APOC3 was found in 42% of the studied tumours, but it was not found to be significantly associated with any of the studied clinical variables, including cancer-specific survival time or survival time after recurrent/metastatic disease. According to the present findings, the putative survival factor gene on 11q23 is not located close enough to the APOC3 gene, but apparently at a more proximal location. © 1999 Cancer Research Campaign

Published
1999

2. European multicenter study on LOH of APOC3 at 11q23 in 766 breast cancer patients: relation to clinical variables. Breast Cancer Somatic Genetics Consortium.

Author

Launonen V, Laake K, Huusko P, Niederacher D, Beckmann MW, Barkardottir RB, Geirsdottir EK, Gudmundsson J, Rio P, Bignon YJ, Seitz S, Scherneck S, Bièche I, Champème MH, Birnbaum D, White G, Varley J, Sztán M, Olah E, Osorio A, Benitez J, Spurr N, Velikonja N, Peterlin B, and Winqvist R

Subjects
Adult, Aged, Aged, 80 and over, Europe, Female, Genetic Markers, Humans, Middle Aged, Apolipoproteins C genetics, Breast Neoplasms genetics, Chromosomes, Human, Pair 11, Loss of Heterozygosity
Abstract

High frequencies of loss of heterozygosity (LOH) in chromosome 11q22-qter have been observed in various malignancies, including breast cancer. Previous studies on breast carcinomas by Winqvist et al (Cancer Res 55: 2660-2664) have indicated that a survival factor gene is located in band 11q23, and that the highly informative microsatellite polymorphism at the APOC3 locus would be a suitable tool to perform more extensive LOH studies. In this European multicentre study, we have examined the occurrence of APOC3 LOH and evaluated the effect of LOH of this chromosomal subregion on the clinical behaviour of the disease in a cohort of 766 breast cancer patients in more detail. LOH for APOC3 was found in 42% of the studied tumours, but it was not found to be significantly associated with any of the studied clinical variables, including cancer-specific survival time or survival time after recurrent/metastatic disease. According to the present findings, the putative survival factor gene on 11q23 is not located close enough to the APOC3 gene, but apparently at a more proximal location.

Published
1999
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3. Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.

Author

Gudmundsson J, Barkardottir RB, Eiriksdottir G, Baldursson T, Arason A, Egilsson V, and Ingvarsson S

Subjects
Blotting, Southern, Chromosome Mapping, DNA, Satellite genetics, Female, Genetic Markers, Heterozygote, Humans, Male, Polymerase Chain Reaction, Polymorphism, Genetic, Prognosis, Breast Neoplasms genetics, Breast Neoplasms, Male genetics, Chromosome Aberrations, Chromosomes, Human, Pair 11, Gene Deletion
Abstract

We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome 11. Three distinct regions of LOH were identified: 11p15.5, 11q13 and 11q22-qter with a LOH frequency of 19, 23 and 37-43% respectively. The marker D11S969 showing the highest frequency of LOH (43%) is located at the 11q24.1-q25 region. No previous molecular genetic studies have shown frequent LOH at the region telomeric to q23 on chromosome 11. Southern analysis revealed that LOH at 11q13 was due to amplification, whereas LOH at 11q22qter was due to deletion. LOH at 11p15.5 was associated with paucity of hormone receptor proteins, high S-phase and positive node status. An association was found between LOH at 11q13 and positive node status. LOH at the 11q22-qter region correlated with a high S-phase fraction. A significant association was found between LOH at 11p15 and chromosome regions 17q21 (the BRCA1 region) and 3p.

Published
1995
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