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Start Over Author "Frigerio L." Journal british journal of cancer
5 results on '"Frigerio L."'

1. Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer

Author

Ansaloni, L, primary, Coccolini, F, additional, Morosi, L, additional, Ballerini, A, additional, Ceresoli, M, additional, Grosso, G, additional, Bertoli, P, additional, Busci, L M, additional, Lotti, M, additional, Cambria, F, additional, Pisano, M, additional, Rossetti, D, additional, Frigerio, L, additional, D'Incalci, M, additional, and Zucchetti, M, additional

Published
2014
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3. Pharmacokinetics of concomitant cisplatin and paclitaxel administered by hyperthermic intraperitoneal chemotherapy to patients with peritoneal carcinomatosis from epithelial ovarian cancer.

Author

Ansaloni, L, Coccolini, F, Morosi, L, Ballerini, A, Ceresoli, M, Grosso, G, Bertoli, P, Busci, L M, Lotti, M, Cambria, F, Pisano, M, Rossetti, D, Frigerio, L, D'Incalci, M, and Zucchetti, M

Subjects
OVARIAN cancer treatment, PERITONEAL cancer, CANCER patients, CISPLATIN, PACLITAXEL, CANCER chemotherapy, PHARMACOKINETICS, DRUG efficacy
Abstract

Background:Hyperthermic intraperitoneal chemotherapy (HIPEC) is advised as a treatment option for epithelial ovarian cancer (EOC) with peritoneal carcinomatosis. This study was designed to define the pharmacokinetics of cisplatin (CDDP) and paclitaxel (PTX) administered together during HIPEC.Methods:Thirteen women with EOC underwent cytoreductive surgery (CRS) and HIPEC, with CDDP and PTX. Blood, peritoneal perfusate and tissue samples were harvested to determine drug exposure by high-performance liquid chromatography and matrix-assisted laser desorption ionization imaging mass spectrometry (IMS).Results:The mean maximum concentrations of CDDP and PTX in perfusate were, respectively, 24.8±10.4 μg ml−1 and 69.8±14.3 μg ml−1; in plasma were 1.87±0.4 μg ml−1 and 0.055±0.009 μg ml−1. The mean concentrations of CDDP and PTX in peritoneum at the end of HIPEC were 23.3±8.0 μg g−1 and 30.1±18.3 μg−1g−1, respectively. The penetration of PTX into the peritoneal wall, determined by IMS, was about 0.5 mm. Grade 3-4 surgical complications were recorded in four patients, five patients presented grade 3 and two patients presented grade 4 hematological complications.Conclusions:HIPEC with CDDP and PTX after CRS is feasible with acceptable morbidity and has a favorable pharmacokinetic profile: high drug concentrations are achieved in peritoneal tissue with low systemic exposure. Larger studies are needed to demonstrate its efficacy in patients with microscopic postsurgical residual tumours in the peritoneal cavity. [ABSTRACT FROM AUTHOR]

Published
2015
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5. Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary

Author

Antonella Savarese, Giovanna Scarfone, Jessica Ottolina, Massimo Candiani, Marco Marinaccio, Giorgio Giorda, Domenica Lorusso, Angiolo Gadducci, L. Frigerio, Enrico Breda, R. Rossi, G. Mangili, Sandro Pignata, Mangili, G, Ottolina, J, Gadducci, A, Giorda, G, Breda, E, Savarese, A, Candiani, Massimo, Frigerio, L, Scarfone, G, Pignata, S, Rossi, R, Marinaccio, M, and Lorusso, D.

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Granulosa cell tumour, survival analysis, granulosa cell tumour of the ovary, Breast cancer, Internal medicine, follow-up, Biomarkers, Tumor, medicine, Humans, Stage (cooking), Survival rate, Aged, Granulosa Cell Tumor, Retrospective Studies, relapse, Aged, 80 and over, Ovarian Neoplasms, Cervical cancer, Granulosa Cells, Proportional hazards model, business.industry, Ovary, prognostic factors, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Survival Rate, Treatment Outcome, Clinical Study, Female, Neoplasm Recurrence, Local, Ovarian cancer, business, Follow-Up Studies
Abstract

Objective: The aim of this study is to evaluate the long-term outcome of granulosa cell tumour (GCT) of the ovary in a large series of patients treated in MITO centres (Multicentre Italian Trials in Ovarian Cancer) and to define prognostic parameters for relapse and survival. Methods: A retrospective multi-institutional review of patients with GCTs of the ovary treated or referred to MITO centres was conducted. Surgical outcome, intraoperative and pathological findings and follow-up data were analysed. Kaplan–Meier and Cox proportional hazards analyses were used to determine the predictors for survival and recurrence. Results: A total of 97 patients with primary GCT of the ovary were identified. The median follow-up period was 88 months (range 6–498). Of these, 33 patients had at least one episode of disease recurrence, with a median time to recurrence of 53 months (range 9–332). Also, 47% of recurrences occurred after 5 years from initial diagnosis. At multivariate analysis, age and stage were independent poor prognostic indicators for survival; surgical treatment outside MITO centres and incomplete surgical staging retained significant predictive value for recurrence in both univariate and multivariate analyses. Conclusions: This study confirms the generally favourable prognosis of GCTs of the ovary, with 5-year overall survival approaching 97%. Nevertheless, prognosis after 20 years was significantly poorer, with 20-year survival rate of 66.8% and a global mortality of 30–35. These findings support the need for lifelong follow-up even in early-stage GCT.

Published
2013

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