1. Inhibition of angiogenesis and murine tumour growth by laminarin sulphate.
- Author
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Hoffman R, Paper DH, Donaldson J, and Vogl H
- Subjects
- Animals, Antineoplastic Agents chemistry, Carbohydrate Sequence, Cattle, Cells, Cultured, Chick Embryo, Collagen, Drug Combinations, Endothelium, Vascular cytology, Laminin, Mice, Mice, Inbred C3H, Models, Biological, Molecular Sequence Data, Polysaccharides chemistry, Proteoglycans, Antineoplastic Agents pharmacology, Neovascularization, Pathologic prevention & control, Neovascularization, Physiologic drug effects, Polysaccharides pharmacology
- Abstract
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).
- Published
- 1996
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