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Start Over Topic polysaccharides Journal british journal of cancer
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1. Inhibition of angiogenesis and murine tumour growth by laminarin sulphate.

Author

Hoffman R, Paper DH, Donaldson J, and Vogl H

Subjects
Animals, Antineoplastic Agents chemistry, Carbohydrate Sequence, Cattle, Cells, Cultured, Chick Embryo, Collagen, Drug Combinations, Endothelium, Vascular cytology, Laminin, Mice, Mice, Inbred C3H, Models, Biological, Molecular Sequence Data, Polysaccharides chemistry, Proteoglycans, Antineoplastic Agents pharmacology, Neovascularization, Pathologic prevention & control, Neovascularization, Physiologic drug effects, Polysaccharides pharmacology
Abstract

LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).

Published
1996
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2. Inhibition of angiogenesis and murine tumour growth by laminarin sulphate

Author

J. Donaldson, D.H. Paper, R. Hoffman, and H. Vogl

Subjects
Cancer Research, Angiogenesis, Basic fibroblast growth factor, Molecular Sequence Data, Neovascularization, Physiologic, Antineoplastic Agents, Chick Embryo, Biology, Models, Biological, Neovascularization, chemistry.chemical_compound, Laminarin, Mice, In vivo, Laminin, Polysaccharides, medicine, Animals, Fibrosarcoma, Cells, Cultured, Matrigel, Mice, Inbred C3H, Neovascularization, Pathologic, medicine.disease, bacterial infections and mycoses, Molecular biology, Drug Combinations, Oncology, chemistry, Carbohydrate Sequence, Immunology, biology.protein, Cattle, Proteoglycans, Collagen, Endothelium, Vascular, medicine.symptom, Research Article
Abstract

LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01). Images Figure 2

Published
1996