1. Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients.
- Author
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Amro A, Chen Y, Barry R, Susick L, Bensenhaver J, Proctor E, Petersen L, Nathanson SD, Ali H, Loutfi R, Chitale D, Simonds A, Kuklinski M, Park KU, Davis M, and Newman LA
- Subjects
- Adult, Black or African American genetics, Aged, Aged, 80 and over, Breast Neoplasms therapy, Female, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Neoplasm Recurrence, Local genetics, Neoplasm Recurrence, Local pathology, Prognosis, Receptor, ErbB-2 metabolism, White People genetics, Breast Neoplasms genetics, Breast Neoplasms pathology, Transcriptome
- Abstract
We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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