1. Breast cancer stem cells: implications for therapy of breast cancer.
- Author
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Morrison BJ, Schmidt CW, Lakhani SR, Reynolds BA, and Lopez JA
- Subjects
- Antigens, Neoplasm metabolism, Breast pathology, Cell Differentiation, Dendritic Cells cytology, Female, Humans, Immunotherapy methods, Neoplasm Metastasis, Neoplastic Stem Cells pathology, Signal Transduction, Stem Cells cytology, Time Factors, Treatment Outcome, Breast Neoplasms diagnosis, Breast Neoplasms pathology, Neoplastic Stem Cells cytology
- Abstract
The concept of cancer stem cells responsible for tumour origin, maintenance, and resistance to treatment has gained prominence in the field of breast cancer research. The therapeutic targeting of these cells has the potential to eliminate residual disease and may become an important component of a multimodality treatment. Recent improvements in immunotherapy targeting of tumour-associated antigens have advanced the prospect of targeting breast cancer stem cells, an approach that might lead to more meaningful clinical remissions. Here, we review the role of stem cells in the healthy breast, the role of breast cancer stem cells in disease, and the potential to target these cells.
- Published
- 2008
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