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Your search keyword '"Taghian, Alphonse G."' showing total 29 results
Start Over Author "Taghian, Alphonse G." Journal breast cancer research and treatment
29 results on '"Taghian, Alphonse G."'

24. Evaluation of radiation-induced cardiac toxicity in breast cancer patients treated with Trastuzumab-based chemotherapy

Author

Abouegylah, Mohamed, primary, Braunstein, Lior Z., additional, Alm El-Din, Mohamed A., additional, Niemierko, Andrzej, additional, Salama, Laura, additional, Elebrashi, Mostafa, additional, Edgington, Samantha K., additional, Remillard, Kyla, additional, Napolitano, Brian, additional, Naoum, George E., additional, Sayegh, Hoda E., additional, Gillespie, Tessa, additional, Farouk, Mohamed, additional, Ismail, Abdelsalam A., additional, and Taghian, Alphonse G., additional

Published
2018
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28. The impact of breast cancer-related lymphedema on the ability to perform upper extremity activities of daily living.

Author

O'Toole JA, Ferguson CM, Swaroop MN, Horick N, Skolny MN, Brunelle CL, Miller CL, Jammallo LS, Specht MC, and Taghian AG

Subjects
Activities of Daily Living, Adult, Aged, Aged, 80 and over, Arm pathology, Breast Neoplasms complications, Breast Neoplasms surgery, Female, Humans, Lymphedema etiology, Mastectomy, Middle Aged, Motor Activity, Prospective Studies, Quality of Life, Arm physiopathology, Breast Neoplasms pathology, Lymphedema physiopathology
Abstract

We sought to assess the association of breast cancer-related lymphedema (BCRL) with the ability to perform upper extremity activities of daily living (ADL) in our patient population. 324 breast cancer patients who had received treatment for unilateral breast cancer at our institution between 2005 and 2014 were prospectively screened for lymphedema. Bilateral arm measurements were performed pre-operatively and during post-operative follow-up using a Perometer. Patients completed an extensive quality of life (QOL) questionnaire at the time of each study assessment. Lymphedema was defined as a relative volume change (RVC) of ≥10% from the patient's pre-operative baseline measurement. Linear regression models were used to evaluate the relationship between post-operative arm function score (as a continuous variable) and RVC, demographic, clinical, and QOL factors. By multivariate analysis, greater fear of lymphedema (p < 0.0001), more pain (p < 0.0001), body mass index >25 (p = 0.0015), mastectomy (p = 0.0001), and having an axillary node dissection (p = 0.0045) were all associated with lower functional scores. Higher emotional well-being score (p < 0.0001) and adjuvant chemotherapy (p = 0.0005) were associated with higher post-operative functional score. Neither low-level volume changes (5-10 % RVC) nor BCRL (RVC ≥10 %) were associated with ability to perform upper extremity ADL as measured by self-report (p = 0.99, p = 0.79). This prospective study demonstrates that low-level changes in arm volume (RVC 5-10 %) as well as clinically significant BCRL (RVC ≥10 %) did not impact the self-reported ability to use the affected extremity for ADL. These findings may help to inform clinicians and patients on the importance of prospective screening for lymphedema and QOL which enables early detection and intervention.

Published
2015
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29. Cording following treatment for breast cancer.

Author

O'Toole J, Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, Elliott K, Niemierko A, and Taghian AG

Subjects
Adult, Aged, Aged, 80 and over, Arm physiopathology, Axilla pathology, Cohort Studies, Female, Humans, Lymphedema etiology, Lymphedema pathology, Middle Aged, Multivariate Analysis, Postoperative Complications epidemiology, Risk Factors, Self Report, Breast Neoplasms pathology, Breast Neoplasms surgery, Postoperative Complications pathology
Abstract

Treatment for breast cancer may result in the formation of palpable cords in the axillary region. Our aim was to evaluate cording incidence, risk factors, and association with upper extremity functional impairment and measured arm volume change. We included 308 patients with unilateral breast cancer prospectively screened for upper extremity lymphedema, symptoms and function. Patients were assessed pre- and post-operatively and at 3-8-month intervals with perometer arm measurements and the LEFT-BC questionnaire. Cording was determined by patient self-report. The cumulative incidence of cording and its association with clinicopathologic factors, upper extremity functional impairment, and measured arm volume change were analyzed. 31.5 % (97/308) of patients reported cording, with a cumulative incidence of 36.2 % at 24 months post-operative. Clinicopathologic factors significantly associated with cording by multivariate analysis included axillary lymph node dissection (p < 0.0001) and younger age at diagnosis (p = 0.0005). Cording was associated with increased functional impairment (p = 0.0018) and an arm volume increase of ≥5 % (p = 0.028). Cording following breast cancer treatment is common, and may occur beyond the post-operative period. Our findings emphasize the importance of identifying patients at high risk for cording, and developing strategies to minimize functional impairment and arm volume elevation associated with cording. Future studies should investigate the effectiveness of interventions for cording following breast cancer treatment.

Published
2013
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