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Start Over Author "Rosner, Bernard A." Journal breast cancer research and treatment
36 results on '"Rosner, Bernard A."'

3. Accounting for individualized competing mortality risks in estimating postmenopausal breast cancer risk

Author

Schonberg, Mara A, Li, Vicky W, Eliassen, A Heather, Davis, Roger B, LaCroix, Andrea Z, McCarthy, Ellen P, Rosner, Bernard A, Chlebowski, Rowan T, Hankinson, Susan E, Marcantonio, Edward R, and Ngo, Long H

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Aging, Prevention, Cancer, Behavioral and Social Science, Breast Cancer, Good Health and Well Being, Adult, Breast Neoplasms, Cause of Death, Female, Follow-Up Studies, Humans, Middle Aged, Models, Statistical, Mortality, Population Surveillance, Postmenopause, Prognosis, Reproducibility of Results, Risk Assessment, Risk Factors, Breast cancer prediction, Competing risks, Older, Clinical Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeAccurate risk assessment is necessary for decision-making around breast cancer prevention. We aimed to develop a breast cancer prediction model for postmenopausal women that would take into account their individualized competing risk of non-breast cancer death.MethodsWe included 73,066 women who completed the 2004 Nurses' Health Study (NHS) questionnaire (all ≥57 years) and followed participants until May 2014. We considered 17 breast cancer risk factors (health behaviors, demographics, family history, reproductive factors) and 7 risk factors for non-breast cancer death (comorbidities, functional dependency) and mammography use. We used competing risk regression to identify factors independently associated with breast cancer. We validated the final model by examining calibration (expected-to-observed ratio of breast cancer incidence, E/O) and discrimination (c-statistic) using 74,887 subjects from the Women's Health Initiative Extension Study (WHI-ES; all were ≥55 years and followed for 5 years).ResultsWithin 5 years, 1.8 % of NHS participants were diagnosed with breast cancer (vs. 2.0 % in WHI-ES, p = 0.02), and 6.6 % experienced non-breast cancer death (vs. 5.2 % in WHI-ES, p

Published
2016

4. Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women

Author

Rosner, Bernard, Eliassen, A Heather, Toriola, Adetunji T, Hankinson, Susan E, Willett, Walter C, Natarajan, Loki, and Colditz, Graham A

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Obesity, Estrogen, Clinical Research, Breast Cancer, Nutrition, Cancer, Aging, Contraception/Reproduction, Algorithms, Breast Neoplasms, Cohort Studies, Female, Humans, Incidence, Middle Aged, Postmenopause, Premenopause, Receptors, Estrogen, Receptors, Progesterone, Risk Factors, Time Factors, Weight Gain, Breast cancer risk, Hormone receptor classification, BMI, Clinical Sciences, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

Obesity is well established as a cause of postmenopausal breast cancer incidence and mortality. In contrast, adiposity in early life reduces breast cancer incidence. However, whether short-term weight change influences breast cancer risk is not well known. We followed a cohort of 77,232 women from 1980 to 2006 (1,445,578 person-years), with routinely updated risk factor information, documenting 4196 incident cases of invasive breast cancer. ER and PR status were obtained from pathology reports and medical records yielding a total of 2033 ER+/PR+ tumors, 595 ER-/PR- tumors, 512 ER+/PR- tumors. The log incidence breast cancer model was used to assess the association of short-term weight gain (over past 4 years) while controlling for average BMI before and after menopause. Short-term weight change was significantly associated with breast cancer risk (RR 1.20; 95 % CI 1.09-1.33) for a 4-year weight gain of ≥15 lbs versus no change (≤5 lbs) (P_trend < 0.001). The association was stronger for premenopausal women (RR 1.38; 95 % CI 1.13-1.69) (P_trend = 0.004) than for postmenopausal women (RR 1.10; 95 % CI 0.97-1.25) (P_trend = 0.063). Short-term weight gain during premenopause had a stronger association for ER+/PR- (RR per 25 lb weight gain = 2.19; 95 % CI 1.33-3.61, P = 0.002) and ER-/PR- breast cancer (RR per 25 lb weight gain = 1.61; 95 % CI 1.09-2.38, P = 0.016) than for ER+/PR+ breast cancer (RR per 25 lb weight gain = 1.13; 95 % CI 0.89-1.43, P = 0.32). There are deleterious effects of short-term weight gain, particularly during pre-menopause, even after controlling for average BMI before and after menopause. The association was stronger for ER+/PR- and ER-/PR- than for ER+/PR+ breast cancer.

Published
2015

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