1. Donor-derived breast cancer in a bone marrow transplantation recipient
- Author
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Golfinopoulos, Vassilis, Pentheroudakis, George, Kamakari, S., Metaxa-Mariatou, V., Pavlidis, Nicholas, Pavlidis, Nicholas [0000-0002-2195-9961], and Pentheroudakis, George [0000-0002-6632-2462]
- Subjects
Transplantation, Homologous/*adverse effects ,Myeloid ,Pathology ,Transplantation Conditioning ,Hematopoietic stem cell ,Metastasis ,Breast cancer ,Epithelial Cells/pathology ,Cell differentiation ,Living Donors ,Medicine ,Neoplasm ,Mastectomy ,Breast epithelium ,Bone Marrow Transplantation ,Breast carcinogenesis ,Neoplastic stem cells ,Neoplastic Stem Cells/*pathology ,Bone Marrow Transplantation/*adverse effects ,DNA, Neoplasm ,Immunohistochemistry ,Cell Transformation, Neoplastic ,Oncology ,Acute Disease ,Neoplastic Stem Cells ,Donor ,Human ,Homologous ,Pluripotent Stem Cells ,medicine.medical_specialty ,Adenocarcinoma/*etiology/genetics/pathology ,Leukemia, Myeloid/surgery ,Adenocarcinoma ,Article ,Epidermal growth factor receptor 2 ,Pluripotent stem cells ,Case report ,Humans ,Cyclophosphamide ,Stromal cells ,Breast adenocarcinoma ,Epithelial Cells ,Dna ,medicine.disease ,Hematopoietic Stem Cells ,Acute granulocytic leukemia ,Hematopoietic Stem Cells/*pathology ,Breast Neoplasms/*etiology/genetics/pathology ,Graft recipient ,Whole body radiation ,Breast neoplasms ,Stromal Cells ,Idarubicin ,Hematopoietic stem cells ,Pluripotent Stem Cells/pathology/*transplantation ,Cancer Research ,Cancer regression ,Epithelial cells ,Bone Marrow Transplantation Recipient ,Short tandem repeat ,Alemtuzumab ,Priority journal ,Leukemia ,Stromal Cells/drug effects/physiology/radiation effects ,Genetic analysis ,Cytarabine ,Cell Differentiation ,Allogenic bone marrow transplantation ,Transplantation conditioning ,Haematopoiesis ,medicine.anatomical_structure ,Leukemia, Myeloid ,Lymphatic Metastasis ,Female ,Breast disease ,Stem cell ,Transplantation Conditioning/adverse effects ,Adult ,Bone marrow transplantation ,Adolescent ,Echomammography ,Lymphatic metastasis ,Histopathology ,Breast Neoplasms ,Transplantation, Homologous ,Living donors ,DNA, Neoplasm/genetics ,Acute disease ,Transplantation ,Neoplastic ,business.industry ,Chimera ,Cancer ,Cell transformation ,Bone marrow ,Bone marrow examination ,business - Abstract
We present the case of a young lady who had been treated for acute myelocytic leukemia at the age of 14 by means of allogeneic bone marrow transplantation, the donor being her sister. At the age of 28 she underwent modified radical mastectomy for invasive breast adenocarcinoma. Genetic analysis revealed chimeric cellular populations on both the tumour and normal tissues of the patient with preponderance of donor-derived cells. We conclude that the patient's epithelia had been repopulated by donor-derived hemopoietic stem cells which gave rise to a malignant mammary neoplasm several years later. The donor remains healthy to date. This case adds weight to the theory of pluripotent normal and neoplastic stem cell histogenesis and emphasizes the pivotal role of supporting host stroma in carcinogenesis. © 2008 Springer Science+Business Media, LLC. 113 2 211 213
- Published
- 2008