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1. A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study

Author

Jennifer D. Brooks, John D. Boice, Jr., Roy E. Shore, Anne S. Reiner, Susan A. Smith, Leslie Bernstein, Julia A. Knight, Charles F. Lynch, Esther M. John, Kathleen E. Malone, Lene Mellemkjaer, Rikke Langballe, Xiaolin Liang, Meghan Woods, Marc Tischkowitz, Patrick Concannon, Daniel O. Stram, and Jonine L. Bernstein

Subjects
Radiation treatment, Reproductive factors, Contralateral breast cancer, WECARE Study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Objective: To examined the impact of reproductive factors on the relationship between radiation treatment (RT) for a first breast cancer and risk of contralateral breast cancer (CBC). Methods: The Women’s Environmental Cancer and Radiation Epidemiology (WECARE) Study is a multi-center, population-based case-control study where cases are women with asynchronous CBC (N = 1521) and controls are women with unilateral breast cancer (N = 2211). Rate ratios (RR) and 95% confidence intervals (CI) were estimated using conditional logistic regression to assess the independent and joint effects of RT (ever/never and location-specific stray radiation dose to the contralateral breast [0, >0-

Published
2020
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