1. Trichosporon asahii causing subcutaneous mycoses in an immunocompetent patient: case report and a minireview
- Author
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Wdson Luis Lima Kruschewsky, Pedro Massaroni-Peçanha, Simone Bravim Maifrede, Marcelo Santos Leite, Tâmea Aparecida Linhares Pôssa, Felipe Alberto-Lei, Rodrigo Cayô, Paulo Mendes Peçanha, and Sarah Santos Gonçalves
- Subjects
Azoles ,Antifungal Agents ,Clinical Microbiology - Research Paper ,Trichosporon ,Basidiomycota ,Trichosporonosis ,Media Technology ,Dermatomycoses ,Humans ,Voriconazole ,Fluconazole ,Microbiology - Abstract
Trichosporon spp. are a constituent of the normal flora of humans that can cause both superficial and invasive infections, mainly in immunocompromised and immunocompetent hosts, respectively. Herein, we a report of Trichosporon asahii causing subcutaneous fungal infection (SFI) in an immunocompetent patient after carpal tunnel surgery. Although susceptible to fluconazole, the treatment of SFI failed even using high doses of this azole. The skin lesion improved following the administration of voriconazole. We conducted a literature minireview searching reports on SFI in immunocompetent patients to check for epidemiological, diagnostic, therapeutic, and outcome characteristics. A total of 32 cases were reported. Despite being uncommon, the clinical suspicion and early diagnosis of SFI in immunocompetent patients undergoing previous surgery are important. Our study indicated that the azoles are the most active antifungal agents against Trichosporon spp., except for fluconazole, and voriconazole can be considered the first therapeutic option. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42770-022-00737-x.
- Published
- 2022