1. Beneficial effect of L-arginine for stroke-like episode in MELAS
- Author
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Masato Mori, Yoichi Sakakihara, Mariko Momoi-Yoshida, Masaya Kubota, and Takanori Yamagata
- Subjects
Stroke-like episode ,Glycerol ,medicine.medical_specialty ,Adolescent ,Prednisolone ,Vasodilator Agents ,Encephalopathy ,Vision Disorders ,Brain damage ,MELAS syndrome ,Arginine ,Nitric Oxide ,Gastroenterology ,Brain Ischemia ,Developmental Neuroscience ,Mitochondrial myopathy ,Seizures ,Internal medicine ,medicine ,MELAS Syndrome ,Humans ,Lactic Acid ,Intensive care medicine ,Stroke ,business.industry ,Brain ,General Medicine ,medicine.disease ,Mitochondria ,Treatment Outcome ,Lactic acidosis ,Pediatrics, Perinatology and Child Health ,Drug Therapy, Combination ,Female ,Neurology (clinical) ,medicine.symptom ,business ,Energy Metabolism ,medicine.drug - Abstract
We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe). Among the three episodes, the symptoms improved earliest and magnetic resonance spectroscopy abnormality was minimal when given L-arginine in addition to prednisolone, glycerol and edalavone. L-arginine administration during the acute phase of MELAS might be a potential therapy to reduce brain damage due to mitochondrial dysfunction.
- Published
- 2003