1. Decoding the role of zebrafish neuroglia in CNS disease modeling
- Author
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Tamara G. Amstislavskaya, LongEn Yang, Konstantin N. Zabegalov, Guojun Hu, Pavel Musienko, Erik T. Alpyshov, Andrey D. Volgin, Aleksander Zhdanov, Tatyana Strekalova, Nazar Serikuly, Murilo S. de Abreu, Jingtao Wang, Konstantin A. Demin, David S. Galstyan, Sergey L. Khatsko, Allan V. Kalueff, Dongmei Wang, Yury Sysoev, and Cai Song
- Subjects
0301 basic medicine ,GROWTH-FACTOR ,Central nervous system ,ved/biology.organism_classification_rank.species ,Danio ,microglia ,neural progenitors ,ADULT ZEBRAFISH ,Blood–brain barrier ,blood-brain-barrier ,in-vivo ,Rodents ,Translational Research, Biomedical ,03 medical and health sciences ,CNS disorders ,0302 clinical medicine ,Central Nervous System Diseases ,medicine ,Animals ,Humans ,SCAR FORMATION ,Model organism ,Zebrafish ,DANIO-RERIO ,Microglia ,biology ,ved/biology ,General Neuroscience ,macroglia ,radial glial-cells ,biology.organism_classification ,Disease Models, Animal ,030104 developmental biology ,medicine.anatomical_structure ,Neuroglia ,SPINAL-CORD REGENERATION ,Signal transduction ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Neuroglia, including microglia and astrocytes, is a critical component of the central nervous system (CNS) that interacts with neurons to modulate brain activity, development, metabolism and signaling pathways. Thus, a better understanding of the role of neuroglia in the brain is critical. Complementing clinical and rodent data, the zebrafish (Danio rerio) is rapidly becoming an important model organism to probe the role of neuroglia in brain disorders. With high genetic and physiological similarity to humans and rodents, zebrafish possess some common (shared), as well as some specific molecular biomarkers and features of neuroglia development and functioning. Studying these common and zebrafish-specific aspects of neuroglia may generate important insights into key brain mechanisms, including neurodevelopmental, neurodegenerative, neuroregenerative and neurological processes. Here, we discuss the biology of neuroglia in humans, rodents and fish, its role in various CNS functions, and further directions of translational research into the role of neuroglia in CNS disorders using zebrafish models.
- Published
- 2021