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Your search keyword '"Tanganelli, Sergio"' showing total 6 results
Start Over Author "Tanganelli, Sergio" Journal brain research
6 results on '"Tanganelli, Sergio"'

6. Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study.

Author

Pistis M, Ferraro L, Pira L, Flore G, Tanganelli S, Gessa GL, and Devoto P

Subjects
Animals, Dopamine analysis, Dronabinol antagonists & inhibitors, Extracellular Space chemistry, Extracellular Space drug effects, Glutamic Acid analysis, Glutamic Acid metabolism, Male, Microdialysis, Piperidines pharmacology, Prefrontal Cortex drug effects, Psychotropic Drugs pharmacology, Pyrazoles pharmacology, Rats, Rats, Sprague-Dawley, Receptors, Drug antagonists & inhibitors, Rimonabant, gamma-Aminobutyric Acid analysis, Dopamine metabolism, Dronabinol pharmacology, Extracellular Space metabolism, Prefrontal Cortex metabolism, gamma-Aminobutyric Acid metabolism
Abstract

Cannabinoid modulation of prefrontal cortex and hippocampus neuronal functioning has been correlated to the disruptive action of marijuana on memory tasks. This study investigates the effects of delta(9)-tetrahydrocannabinol (delta(9)-THC) on dopamine, glutamate and GABA levels in vivo by brain microdialysis in the prefrontal cortex. Delta(9)-THC (1 mg/kg, i.v.) significantly increased extracellular dopamine and glutamate levels and decreased GABA levels. These effects were prevented by the cannabinoid antagonist SR141716A (1 mg/kg, i.v.), which per se was ineffective. These results suggest that delta(9)-THC disrupt the normal interplay between neurotransmitters in this area and may bear relevance in understanding neuronal mechanisms underlying cannabinoid-induced cognitive deficits., (Copyright 2002 Elsevier Science B.V.)

Published
2002
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