1. Organum vasculosum laminae terminalis (OVLT) is a brain site to produce interleukin-1 beta during fever
- Author
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Kazuhito Yamaguchi, Nancy C. Long, T Nakamori, Tatsuo Watanabe, N Murakami, and Akio Morimoto
- Subjects
Lipopolysaccharides ,Male ,Pathology ,medicine.medical_specialty ,Fever ,General Neuroscience ,In situ hybridization ,Biology ,Salmonella typhi ,Cerebral Ventricles ,Interleukin 1β ,Endotoxins ,Immunoenzyme Techniques ,Immunology ,medicine ,Immunohistochemistry ,Animals ,Neurology (clinical) ,Rabbits ,Molecular Biology ,Organum vasculosum laminae terminalis ,In Situ Hybridization ,Developmental Biology ,Interleukin-1 - Abstract
The present study was carried out to determine whether interleukin-1 (IL-1) production occurs in the rabbit organum vasculosum laminae terminalis (OVLT) during fever induced by endotoxin. The intravenous (i.v.) injection of endotoxin (4 micrograms/kg) caused significant fever in rabbits. Through the use of in situ hybridization and immunohistochemical techniques, the synthesis of IL-1 was observed in the OVLT during the fever. The present results support the hypothesis that IL-1 is produced in the brain during fever.
- Published
- 1993