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Your search keyword '"Lee, Hyoung-Gon"' showing total 5 results
Start Over Author "Lee, Hyoung-Gon" Journal brain research
5 results on '"Lee, Hyoung-Gon"'

5. Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease.

Author

Lee HG, Ueda M, Miyamoto Y, Yoneda Y, Perry G, Smith MA, and Zhu X

Subjects
Actins metabolism, Aged, Aged, 80 and over, Alzheimer Disease metabolism, Case-Control Studies, Humans, Immunohistochemistry methods, Neurofibrillary Tangles metabolism, Pick Disease of the Brain metabolism, Pick Disease of the Brain pathology, Alzheimer Disease pathology, Hippocampus pathology, Neurons metabolism, alpha Karyopherins metabolism
Abstract

Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.

Published
2006
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