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9. Long lasting effects of intrauterine growth retardation of 5-HT metabolism in the brain of developing rats.

Author

Chanez C, Priam M, Flexor MA, Hamon M, Bourgoin S, Kordon C, and Minkowski A

Subjects
Animals, Dopamine metabolism, Female, Hydroxyindoleacetic Acid metabolism, Maternal-Fetal Exchange, Norepinephrine metabolism, Pregnancy, Rats, Tryptophan metabolism, Tyrosine metabolism, Brain metabolism, Fetal Growth Retardation metabolism, Serotonin metabolism
Abstract

Intrauterine growth retardation (IUGR) was achieved by ligating the artery and vein supplying one uterine horn in pregnant rats on the 5th day before delivery. At birth, the weight of the whole body and of the forebrain (but not that of the brain stem of about half of the offspring) were significantly lower than those of normal controls. This deficit persisted for at least the first 3 postnatal weeks. During the immediate period following birth, the concentrations of norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in IUGR rats than in controls. Increased levels of serotonin and 5-HIAA were still observed in the forebrain and brain stem of 15-day-old IUGR rats and were associated with parallel increases in brain and serum free tryptophan levels. These results indicate that a transient insult in the fetal life could result in long-lasting alterations in 5-HT metabolism in CNS of developing rats.

Published
1981
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10. Vasoactive intestinal peptide (VIP): brain distribution, subcellular localization and effect of deafferentation of the hypothalamus in male rats.

Author

Besson J, Rotsztejn W, Laburthe M, Epelbaum J, Beaudet A, Kordon C, and Rosselin G

Subjects
Afferent Pathways physiology, Animals, Hypothalamus metabolism, Male, Neurons metabolism, Radioimmunoassay, Rats, Subcellular Fractions metabolism, Brain metabolism, Gastrointestinal Hormones metabolism, Hypothalamus physiology, Vasoactive Intestinal Peptide metabolism
Published
1979
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