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2. Histamine synthesis inhibition reduces light-induced phase shifts of circadian rhythms.

Author

Eaton SJ, Cote NK, and Harrington ME

Subjects
Animals, Cricetinae, Enzyme Inhibitors pharmacology, Histidine Decarboxylase antagonists & inhibitors, Male, Mesocricetus, Methylhistidines pharmacology, Motor Activity drug effects, Motor Activity physiology, Photic Stimulation, Suprachiasmatic Nucleus drug effects, Suprachiasmatic Nucleus physiology, Circadian Rhythm drug effects, Histamine biosynthesis, Histamine Antagonists pharmacology
Abstract

Circadian rhythms are generated by the hypothalamic suprachiasmatic nuclei, a site of dense histaminergic innervation. Histamine can phase shift circadian rhythms in a manner similar to light. In this experiment, we administered alpha-fluoromethylhistidine (FMH), an inhibitor of histamine synthesis, prior to a light pulse in hamsters housed under constant darkness. Photic phase shifts in wheel-running rhythms were significantly attenuated by FMH pretreatment. These results suggest that histamine may modulate photic input to the circadian clock.

Published
1995
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