1. Effects of cycloheximide on delayed neuronal death in rat hippocampus
- Author
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Mitsutoshi Yuzurihara, Kyoji Sekiguchi, Masaki Aburada, Eikichi Hosoya, Akira Sugimoto, Kyuya Kogure, Kazuhiro Goto, Susumu Iizuka, and Atsushi Ishige
- Subjects
Male ,Programmed cell death ,medicine.medical_specialty ,Time Factors ,Cell Survival ,Pyramidal Tracts ,Hippocampus ,Cycloheximide ,Biology ,Hippocampal formation ,Forebrain ischemia ,chemistry.chemical_compound ,Neuronal damage ,Internal medicine ,Ischemic insult ,medicine ,Protein biosynthesis ,Animals ,Molecular Biology ,Neurons ,General Neuroscience ,Rats, Inbred Strains ,Rats ,Endocrinology ,nervous system ,chemistry ,Ischemic Attack, Transient ,Neurology (clinical) ,Neuroscience ,Developmental Biology - Abstract
The effect of cycloheximide, a protein synthesis inhibitor, on hippocampal selective neuronal death was morphologically studied in rats subjected to 10 min forebrain ischemia using a 4-vessel occlusion model. Neuronal damage in the hippocampal CA1 subfield 72 h after ischemic insult was dramatically decreased by the lasting inhibition of protein synthesis through consecutive administration of cycloheximide. Cycloheximide, which was administered once within the first 24 h of recirculation, showed protective action on ischemic cell necrosis and its most potent effect was observed when injected at 12 h of post-ischemia. After 36 h of recirculation, however, treatment with cycloheximide could no longer prevent cell death. The possibility is considered that hippocampal delayed neuronal death following transient ischemia is caused by abnormal protein(s).
- Published
- 1990