1. Positive blood alcohol level in severe traumatic brain injury is associated with better long-term functional outcome.
- Author
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Mohseni, Shahin, Bellander, Bo-Michael, Riddez, Louis, Talving, Peep, and Thelin, Eric P.
- Subjects
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BRAIN injuries , *CHEMILUMINESCENCE assay , *CHI-squared test , *CONFIDENCE intervals , *DRUG use testing , *ETHANOL , *FISHER exact test , *LENGTH of stay in hospitals , *IMMUNOASSAY , *INTENSIVE care units , *LIFE skills , *HEALTH outcome assessment , *QUESTIONNAIRES , *STATISTICS , *T-test (Statistics) , *TRAUMA centers , *MULTIPLE regression analysis , *RETROSPECTIVE studies , *SEVERITY of illness index , *DATA analysis software , *FUNCTIONAL assessment , *DESCRIPTIVE statistics , *TRAUMA registries , *TRAUMA severity indices , *ALCOHOLIC intoxication , *ODDS ratio , *MANN Whitney U Test , *PROGNOSIS ,BRAIN metabolism - Abstract
Objective: To investigate the association between positive blood alcohol level (BAL) and functional outcome in patients suffering severe traumatic brain injury. Study design: The brain trauma registry of an academic trauma centre was queried for patients admitted between January 2007 and December 2011. All patients (≥ 18 years) with a neurosurgical intensive care length of stay beyond 2 days were included. Patient demographics, clinical characteristics, injury profile, laboratory test and outcomes were abstracted for analysis. Primary outcome was unfavourable functional outcome defined as Glasgow Outcome Score (GOS) ≤ 3. Multivariable regression models were used for analysis. Results: Of the 352 patients, 39% were BAL (+) at admission. Patients with (+) BAL were significantly younger with less co-morbidities. The cohorts exhibited no significant difference in the severity of the intra-cranial injury and the use of intra-cranial monitoring or surgical interventions. Further, the groups presented no difference in in-hospital mortality (p= 0.1) or 1-year mortality (p= 0.5). There was a worse long-term functional outcome in (–) BAL patients compared to their BAL (+) counterparts after adjustment for confounders (GOS ≤ 3: AOR = 2.0, 95% CI = 1.1–3.5,p= 0.02). Conclusion: Positive BAL on admission is associated with a better long-term functional outcome in patients suffering severe traumatic brain injury. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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