1. Disability and health-related quality-of-life 4 years after a severe traumatic brain injury: A structural equation modelling analysis.
- Author
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Azouvi, Philippe, Ghout, Idir, Bayen, Eleonore, Darnoux, Emmanuelle, Azerad, Sylvie, Ruet, Alexis, Vallat-Azouvi, Claire, Pradat-Diehl, Pascale, Aegerter, Philippe, Charanton, James, and Jourdan, Claire
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COMPLICATIONS of brain injuries , *AFFECT (Psychology) , *BRAIN injuries , *CHI-squared test , *CHRONIC diseases , *COGNITION , *FUNCTIONAL assessment , *FISHER exact test , *INTENSIVE care units , *INTERVIEWING , *LIFE skills , *LONGITUDINAL method , *MATHEMATICAL models , *NEUROPSYCHOLOGICAL tests , *RESEARCH methodology , *EVALUATION of medical care , *MEDICAL cooperation , *PATH analysis (Statistics) , *QUALITY of life , *QUESTIONNAIRES , *REGRESSION analysis , *RESEARCH , *RESEARCH funding , *SCALE analysis (Psychology) , *SOCIAL skills , *STATISTICS , *THEORY , *DATA analysis , *ACTIVITIES of daily living , *SECONDARY analysis , *SOCIOECONOMIC factors , *STRUCTURAL equation modeling , *SEVERITY of illness index , *DATA analysis software , *DESCRIPTIVE statistics , *MANN Whitney U Test , *PROGNOSIS - Abstract
Objectives: To assess predictors and indicators of disability and quality-of-life 4 years after severe traumatic brain injury (TBI), using structural equation modelling (SEM). Methods: The PariS-TBI study is a longitudinal multi-centre inception cohort study of 504 patients with severe TBI. Among 245 survivors, 147 patients were evaluated upon 4-year follow-up, and 85 completed the full assessment. Two outcome measures were analysed separately using SEM: the Glasgow Outcome Scale-extended (GOS-E), to measure disability, and the QOLIBRI, to assess quality-of-life. Four groups of variables were entered in the model: demographics; injury severity; mood and cognitive impairments; somatic impairments. Results: The GOS-E was directly significantly related to mood and cognition, injury severity, and somatic impairments. Age and education had an indirect effect, mediated by mood/cognition or somatic deficiencies. In contrast, the only direct predictor of QOLIBRI was mood and cognition. Age and somatic impairments had an indirect influence on the QOLIBRI. Conclusion: Although this study should be considered as explorative, it suggests that disability and quality-of-life were directly influenced by different factors. While disability appeared to result from an interaction of a wide range of factors, quality-of-life was solely directly related to psycho-cognitive factors. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
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