1. Beneficial effect of L-arginine for stroke-like episode in MELAS.
- Author
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Kubota M, Sakakihara Y, Mori M, Yamagata T, and Momoi-Yoshida M
- Subjects
- Adolescent, Brain drug effects, Brain metabolism, Brain physiopathology, Drug Therapy, Combination, Energy Metabolism drug effects, Female, Glycerol therapeutic use, Humans, Lactic Acid metabolism, MELAS Syndrome diagnosis, MELAS Syndrome physiopathology, Mitochondria drug effects, Mitochondria metabolism, Nitric Oxide metabolism, Prednisolone therapeutic use, Seizures drug therapy, Seizures etiology, Seizures physiopathology, Stroke diagnosis, Stroke etiology, Treatment Outcome, Vasodilator Agents therapeutic use, Vision Disorders drug therapy, Vision Disorders etiology, Vision Disorders physiopathology, Arginine therapeutic use, Brain Ischemia prevention & control, MELAS Syndrome drug therapy, Stroke drug therapy
- Abstract
We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe). Among the three episodes, the symptoms improved earliest and magnetic resonance spectroscopy abnormality was minimal when given L-arginine in addition to prednisolone, glycerol and edalavone. L-arginine administration during the acute phase of MELAS might be a potential therapy to reduce brain damage due to mitochondrial dysfunction.
- Published
- 2004
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