1. Longitudinal decline in speech production in Parkinson's disease spectrum disorders
- Author
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Lama M. Chahine, Daniel Weintraub, David J. Irwin, Corey T. McMillan, Nabila Dahodwala, Sophia Dominguez Perez, Olga L. Kofman, Collin York, Amy Halpin, Kim Firn, Murray Grossman, Meredith Spindler, Rachel Langey, Sharon Ash, and Charles Jester
- Subjects
Linguistics and Language ,Speech production ,medicine.medical_specialty ,Parkinson's disease ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Audiology ,Neuropsychological Tests ,050105 experimental psychology ,Language and Linguistics ,Article ,Developmental psychology ,03 medical and health sciences ,Speech and Hearing ,Fluency ,0302 clinical medicine ,Motor system ,medicine ,Dementia ,Humans ,Speech ,0501 psychology and cognitive sciences ,Longitudinal Studies ,Age of Onset ,Gray Matter ,Aged ,Brain Mapping ,Language Disorders ,Narration ,05 social sciences ,Disease spectrum ,Motor Cortex ,Cognition ,Linguistics ,Parkinson Disease ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychology ,030217 neurology & neurosurgery - Abstract
We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24 months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. PDSD patients with dementia exhibited significant decline in their speech, unrelated to changes in overall cognitive or motor functioning. Regression analysis in a subset of patients with MRI scans (n=11) revealed that impaired language performance at Time 2 was associated with reduced gray matter (GM) volume at Time 1 in regions of interest important for language functioning but not with reduced GM volume in motor brain areas. These results dissociate language and motor systems and highlight the importance of non-motor brain regions for declining language in PDSD.
- Published
- 2016