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The effects of a 3 mg/kg body weight (BW) dose of caffeine were assessed on behavioral indices of response inhibition. To meet these aims, we selected a modified AX version of the Continuous Performance Test (CPT), the stop task, and the flanker task. In three double-blind, placebo-controlled, within-subjects experiments, these tasks were administered to healthy participants. While the results for the AX-CPT were indicative of improved response inhibition after caffeine, they might also reflect caffeine-induced changes in mechanisms other than response inhibition (e.g., attentional processes). The results for the stop task and flanker task were more straightforward. That is, the effects of caffeine on overall flanker performance and selective response suppression as revealed by distribution-analytical techniques were negligible. In the stop task a global effect of caffeine on processing speed was seen, rather than specific effects on response inhibition. Taken together, these experiments showed that both active and reactive inhibition were not significantly modulated by caffeine. The present results are linked to neural circuits that underlie inhibitory control and the role of caffeine-induced strategic changes. (Contains 3 tables and 3 figures.)

This event-related potential study investigated (i) to what extent incongruence between attention-directing cue and cued target modality affects attentional control processes that bias the system in advance to favor a particular stimulus modality and (ii) to what extent top-down attentional control mechanisms are generalized for the type of information that is to be attended. To this end, both visual and auditory word cues were used to instruct participants to direct attention to a specific visual (color) or auditory (pitch) stimulus feature of a forthcoming multisensory target stimulus. Effects of cue congruency were observed within 200 ms post-cue over frontal scalp regions and related to processes involved in shifting attention from the cue modality to the modality of the task-relevant target feature. Both directing visual attention and directing auditory attention were associated with dorsal posterior positivity, followed by sustained fronto-central negativity. However, this fronto-central negativity appeared to have an earlier onset and was more pronounced when the visual modality was cued. Together the present results suggest that the mechanisms involved in deploying attention are to some extent determined by the modality (visual, auditory) in which attention operates, and in addition, that some of these mechanisms can also be affected by cue congruency.