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Your search keyword '"hippocampal volumes"' showing total 2 results
Start Over Descriptor "hippocampal volumes" Journal brain and behavior
2 results on '"hippocampal volumes"'

1. Electroconvulsive treatment prevents chronic restraint stress-induced atrophy of the hippocampal formation-A stereological study

Author

Bente Pakkenberg, Johanne L. Alemu, Bushra Azam, Frederik Elberling, and Mikkel V. Olesen

Subjects
Male, medicine.medical_treatment, Hippocampus, Cell Count, Stereology, Hippocampal formation, behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, Behavioral Neuroscience, hippocampal volumes, 0302 clinical medicine, Electroconvulsive therapy, Atrophy, mental disorders, cell numbers, medicine, Animals, 0501 psychology and cognitive sciences, Depression model, Electroconvulsive Therapy, Original Research, Neurons, Depressive Disorder, Major, business.industry, 05 social sciences, chronic restraint stress, Organ Size, medicine.disease, Rats, Disease Models, Animal, nervous system, Major depressive disorder, electroconvulsive stimulation, Restraint stress, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Introduction: Electroconvulsive therapy (ECT) is one of the most efficient treatments of major depressive disorder (MDD), although the underlying neurobiology remains poorly understood. There is evidence that ECT and MDD exert opposing effects on the hippocampal formation with respect to volume and number of neurons. However, there has been a paucity of quantitative data in experimental models of ECT and MDD. Methods: Using design-based stereology, we have measured the effects of a stress-induced depression model (chronic restraint stress, CRS) and ECS on the morphology of the hippocampus by estimating the volume and total number of neurons in the hilus, CA1, and CA2/3, as well as in the entire hippocampus. Results: We find that CRS induces a significant decrease in volume exclusively of the hilus and that ECS (CRS + ECS) blocks this reduction. Furthermore, ECS alone does not change the volume or total number of neurons in the entire hippocampus or any hippocampal subdivision in our rat model.

Published
2019
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2. Electroconvulsive treatment prevents chronic restraint stress-induced atrophy of the hippocampal formation-A stereological study.

Author

Alemu JL, Elberling F, Azam B, Pakkenberg B, and Olesen MV

Subjects
Animals, Atrophy etiology, Atrophy pathology, Atrophy prevention & control, Cell Count methods, Disease Models, Animal, Male, Neurons, Organ Size, Rats, Depressive Disorder, Major pathology, Depressive Disorder, Major therapy, Electroconvulsive Therapy methods, Hippocampus pathology
Abstract

Introduction: Electroconvulsive therapy (ECT) is one of the most efficient treatments of major depressive disorder (MDD), although the underlying neurobiology remains poorly understood. There is evidence that ECT and MDD exert opposing effects on the hippocampal formation with respect to volume and number of neurons. However, there has been a paucity of quantitative data in experimental models of ECT and MDD., Methods: Using design-based stereology, we have measured the effects of a stress-induced depression model (chronic restraint stress, CRS) and ECS on the morphology of the hippocampus by estimating the volume and total number of neurons in the hilus, CA1, and CA2/3, as well as in the entire hippocampus., Results: We find that CRS induces a significant decrease in volume exclusively of the hilus and that ECS (CRS + ECS) blocks this reduction. Furthermore, ECS alone does not change the volume or total number of neurons in the entire hippocampus or any hippocampal subdivision in our rat model., (© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.)

Published
2019
Full Text
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