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Start Over Author "Vasta, S." Journal bone marrow transplantation
5 results on '"Vasta, S."'

3. High incidence of chronic GVHD after primary allogeneic peripheral blood stem cell transplantation in patients with hematologic malignancies.

Author

Majolino I, Saglio G, Scimè R, Serra A, Cavallaro AM, Fiandaca T, Vasta S, Pampinella M, Catania P, Indovina A, Marcenò R, and Santoro A

Subjects
Adult, Busulfan, Chimera, Cyclophosphamide, Female, Graft vs Host Disease etiology, Hematologic Neoplasms drug therapy, Hematologic Neoplasms mortality, Histocompatibility, Humans, Immunosuppressive Agents therapeutic use, Male, Middle Aged, Retrospective Studies, Survival Analysis, T-Lymphocytes, Cytotoxic transplantation, Transplantation Conditioning, Transplantation, Homologous, Treatment Outcome, Graft vs Host Disease epidemiology, Hematologic Neoplasms therapy, Hematopoietic Stem Cell Transplantation adverse effects, T-Lymphocytes, Cytotoxic immunology
Abstract

To assess feasibility and potential advantages of PBSC allograft, we transplanted nine patients (age 20-47 years) with advanced or poor-risk hematologic malignancies. These included eight HLA-identical sibling transplants and one partially matched. Cells were collected from donors by apheresis after rh-G-CSF 10-16 micrograms/kg/day for 4-5 days, and stored at 4 degrees C until infusion. Patients were conditioned with busulfan 16 mg/kg and cyclophosphamide 200 mg/kg, and received GVHD prophylaxis with CSA-MTX. The graft consisted of PBSC alone, with a median of 101.2 (range 28-254.2) x 10(4)/kg CFU-GM, 6.84 (range 4.57-15.9) x 10(6)/kg CD34+ cells and 2.5 (range 1.2-6) x 10(8)/kg CD3+ cells. An ANC > 0.5 x 10(9)/1 occurred on (median) day 13 range 11-17), and a platelet count > 50 x 10(9)/l on (median) day 15 (range 12-29) post graft. One patient died of ARDS on day 13, the others are alive 96-485 (median 245) days from the graft. Two patients have relapsed, one of them with isolated CNS involvement. Acute GVHD (grade I-II) occurred in three patients and severe chronic GVHD in six patients, with no relationship to CSA withdrawal. This unexpected incidence of chronic GVHD might be linked to the high number of CD3+ cells in the graft, contributing to a favourable GVL effect.

Published
1996

4. Autologous stem cell transplantation in amyloidosis AL.

Author

Majolino I, Marceno R, Pecoraro G, Scime R, Vasta S, Liberti G, Rizzo A, Indovina A, and Caronia F

Subjects
Blood Transfusion, Autologous, Female, Humans, Middle Aged, Multiple Myeloma surgery, Amyloidosis surgery, Bone Marrow Transplantation methods, Hematopoietic Stem Cell Transplantation
Published
1993

5. Poor circulating CFU-GM harvest and slow hematologic reconstitution in a patient with chronic granulocytic leukemia undergoing autologous transplantation.

Author

Vasta S, Santoro A, Barbata G, Granata G, Indovina A, Gentile S, Tringali S, and Majolino I

Subjects
Adolescent, Colony-Forming Units Assay, Female, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive surgery, Leukemia, Myeloid, Chronic-Phase pathology, Transplantation, Autologous, Bone Marrow Transplantation pathology, Leukemia, Myeloid, Chronic-Phase surgery
Published
1991

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