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Your search keyword '"Kishi, Y."' showing total 18 results
Start Over Author "Kishi, Y." Journal bone marrow transplantation
18 results on '"Kishi, Y."'

17. Feasibility of reduced intensity hematopoietic stem cell transplantation from an HLA-matched unrelated donor.

Author

Hori, A., Kim, S. -W., Kusumi, E., Kami, M., Yuji, K., Hamaki, T., Murashige, N., Kojima, R., Kishi, Y., Ueyama, J., Miyakoshi, S., Tanosaki, R., Morinaga, S., Mori, S., Heike, Y., Muto, Y., Masuo, S., Taniguchi, S., and Takaue, Y.

Subjects
CELL transplantation, TRANSPLANTATION of organs, tissues, etc., ORGAN donation, FLUDARABINE, CYCLOSPORINE
Abstract

Summary:To evaluate the feasibility of reduced intensity stem cell transplantation (RIST) with bone marrow from a matched unrelated donor (MUD), we retrospectively investigated 20 patients with hematological disorders who received RIST in the Tokyo SCT consortium from January 2000 to October 2002. The preparative regimens were fludarabine-based (150-180?mg/m2, n=18) or cladribine-based (0.77?mg/kg, n=2). To enhance engraftment, antithymocyte globulin (ATG) and 4 or 8?Gy total body irradiation (TBI) were added to these regimens in nine and 11 patients, respectively. GVHD prophylaxis was cyclosporine with or without methotrexate. In all, 19 achieved primary engraftment. Three developed graft failure (one primary, two secondary), and five died of treatment-related mortality within 100 days of transplant. Seven of the 19 patients who achieved initial engraftment developed grade II-IV acute GVHD, and seven of 13 patients who survived >100 days developed chronic GVHD. At a median follow-up of 5.5 months, estimated 1-year overall survival was 35%. Compared with a TBI-containing regimen, an ATG-containing regimen was associated with a high risk of graft failure (30 vs 0%, P=0.0737). This study supports the feasibility of RIST from MUD; however, procedure-related toxicities remain significant in its application to patients.Bone Marrow Transplantation (2004) 33, 697-702. doi:10.1038/sj.bmt.1704425 Published online 2 February 2004 [ABSTRACT FROM AUTHOR]

Published
2004
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18. Hyperacute GVHD and emergence of peripheral CD3+CD56+T cells and activated natural killer cells are useful markers for early diagnosis of post-transplant hemophagocytic syndrome.

Author

Kishi, Y, Kami, M, Murashige, N, Tanaka, Y, Haraguchi, K, Fujisaki, G, Kusumoto, S, Mori, S-I, Takaue, Y, and Tanosaki, R

Subjects
*LETTERS to the editor, *GRAFT versus host disease
Abstract

Presents the letter to the editor about an article on graft-versus-host disease, published in a previous issue of the journal.

Published
2005
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