1. Onion decreases the ovariectomy-induced osteopenia in young adult rats
- Author
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Yu-Ting Lai, R. C. Mühlbauer, Tsang Hai Huang, Rong-Sen Yang, Guan Liang Chang, Wei Ting Yang, Hsin Shi Lin, Hsiun Ing Chen, Chih-Hsin Tang, and Yi Wei Huang
- Subjects
Male ,medicine.medical_specialty ,Histology ,Physiology ,Ovariectomy ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Bone and Bones ,Bone resorption ,Bone remodeling ,Osteoclast ,Internal medicine ,Onions ,medicine ,Animals ,Humans ,Rats, Wistar ,Alendronate ,Bone Density Conservation Agents ,Dose-Response Relationship, Drug ,Plant Extracts ,Chemistry ,Alendronic acid ,medicine.disease ,Diet ,Rats ,Osteopenia ,Bone Diseases, Metabolic ,Dose–response relationship ,medicine.anatomical_structure ,Endocrinology ,Ovariectomized rat ,Female ,Biomarkers ,medicine.drug - Abstract
It has been suggested that fruit and vegetable consumption are associated with good bone health. Onion, in particular, has been verified in its efficacy in bone resorption activity. In this study, we further investigated the effects of an onion-containing diet on ovariectomy-induced bone loss using methods of serum marker assay, histomorphometric analysis and biomechanical tests. Sixty-four female Wistar rats (14-week-old) with sham operations or ovariectomy were assigned to 6 groups: CON, sham-operated control group; OVX, ovariectomized group; ALN, ovariectomized rats treated with alendronate (1 mg/kg/day, p.o.); and 3% ON, 7% ON and 14% ON, ovariectomized rats fed with diets containing 3%, 7% and 14% (wt/wt) onion powder, respectively. Animals were sacrificed after a six-week treatment course. In the serum marker assay, alendronate and all three onion-enriched diets significantly decreased serum calcium level (p
- Published
- 2008
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