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6. Oncogenous osteomalacia: a new case secondary to a malignant tumor.

Author

Rico H, Fernandez-Miranda E, Sanz J, Gomez-Castresana F, Escriba A, Hernandez ER, and Krsnik I

Subjects
Adult, Blood Coagulation Factors antagonists & inhibitors, Blood Coagulation Factors blood, Histiocytoma, Benign Fibrous blood, Histiocytoma, Benign Fibrous pathology, Humans, Lupus Coagulation Inhibitor, Male, Osteomalacia blood, Phosphates blood, Soft Tissue Neoplasms blood, Soft Tissue Neoplasms pathology, Histiocytoma, Benign Fibrous complications, Osteomalacia etiology, Soft Tissue Neoplasms complications
Abstract

A case of oncogenous osteomalacia secondary to a fibrous malignant histiocytoma in a 31-year-old male is described. The patient also demonstrated a lupuslike anticoagulant. Clinical signs of osteomalacia preceded by 9 years those of the tumor, a feature occurring in only 8% of these malignancies. Surgical resection of the tumor and surrounding tissues was followed by a clinical improvement and a return to normal of serum phosphorus and tubular reabsorption of phosphate, though the lupuslike anticoagulant persisted. This first description of a fibrous malignant histiocytoma with associated osteomalacia and lupuslike anticoagulant makes compulsory the inclusion of these syndromes among those already described that may appear with this tumor.

Published
1986
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