1. Injectable bone substitute using a hydrophilic polymer
- Author
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Guy Daculsi, Olivier Gauthier, Pierre Weiss, Gael Grimandi, Jean-Michel Bouler, Matériaux d'intérêt biologique, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Weiss, Pierre
- Subjects
Calcium Phosphates ,Physiology ,Endocrinology, Diabetes and Metabolism ,Composite number ,Biocompatible Materials ,Lactose ,02 engineering and technology ,Matrix (biology) ,MESH: Bone Regeneration ,MESH: Dogs ,MESH: Methylcellulose ,Hydrophilic polymers ,Implants, Experimental ,MESH: Biocompatible Materials ,Materials Testing ,MESH: Animals ,Femur ,Ceramic ,MESH: Bone Substit ,chemistry.chemical_classification ,MESH: Statistics, Nonparametric ,0303 health sciences ,Viscosity ,MESH: Tooth Socket ,Biomaterial ,Polymer ,MESH: Calcium Phosphates ,021001 nanoscience & nanotechnology ,3. Good health ,MESH: Drug Carriers ,visual_art ,visual_art.visual_art_medium ,Rabbits ,Rheology ,0210 nano-technology ,medicine.medical_specialty ,Histology ,Materials science ,MESH: Tooth Extraction ,MESH: Bone Substitutes ,Methylcellulose ,Injections ,03 medical and health sciences ,MESH: Ceramics ,Oxazines ,medicine ,Injectable bone ,Animals ,MESH: Injections ,[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials ,030304 developmental biology ,MESH: Pilot Projects ,Surgery ,[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials ,chemistry ,Chemical engineering ,Bone Substitutes ,MESH: Female - Abstract
We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to obtain CaP bioactivity in a dental canal or bone defect during percutaneous surgery. Macromolecules provide spaces between CaP ceramic granules and facilitate the role of the biological agents of bone substitution.
- Published
- 1999