1. Phenotypic characterization of Grm1
- Author
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Ilaria, Musante, Deborah, Mattinzoli, Lavinia Alexandra, Otescu, Simone, Bossi, Masami, Ikehata, Chiara, Gentili, Giuliana, Cangemi, Cinzia, Gatti, Laura, Emionite, Piergiorgio, Messa, Roberto, Ravazzolo, Maria Pia, Rastaldi, Daniela, Riccardi, and Aldamaria, Puliti
- Subjects
Male ,Mice, Inbred BALB C ,Bone Development ,Osteoblasts ,Osteoclasts ,Cell Differentiation ,Organ Size ,Receptors, Metabotropic Glutamate ,Calcification, Physiologic ,Phenotype ,Bone Density ,Animals ,Body Size ,Female - Abstract
Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glutamate signaling in bone is poorly understood. Specifically type 1 metabotropic glutamate (mGlu1) receptors are expressed in bone, but the effect of its ablation on skeletal development has never been investigated. Here we report that Grm1
- Published
- 2015