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165 results on '"Boland, A"'

3. Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene

Author

Diana Zelenika, Frédéric Jehan, Valérie Geoffroy, Anne Boland, Agnès Ostertag, Leila Lhaneche, Didier Hannouche, Bente L. Langdahl, Aline Domingues, Martine Cohen-Solal, Jannie Dahl Hald, Marc Delepine, Marie-Christine de Vernejoul, and Torben Harsløf

Subjects
0301 basic medicine, Adult, Genetic Markers, Male, medicine.medical_specialty, Histology, Bone density, Adolescent, Physiology, Endocrinology, Diabetes and Metabolism, Gene Expression, Biology, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Fractures, Bone, Young Adult, Bone Density, Internal medicine, medicine, Humans, Epigenetics, RNA, Messenger, Allele, Adaptor Proteins, Signal Transducing, Aged, Bone mineral, Aged, 80 and over, Polymorphism, Genetic, Genetic Variation, Methylation, DNA Methylation, Middle Aged, Osteogenesis Imperfecta, 030104 developmental biology, Endocrinology, chemistry, CpG site, DNA methylation, Bone Morphogenetic Proteins, Sclerostin, Female
Abstract

SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samples from women, we found that rs851054 (G/A) is associated with SOST mRNA expression, donors with one or two G allele(s) displaying higher SOST expression (p

Published
2016

10. Involvement of AR, ER, PKCΔ, JNK and MnSOD in 17ß-estradiol and testosterone antiapoptotic effects in C2C12 skeletal muscle cells

Author

Ricardo Boland, Lorena Magdalena Milanesi, Andrea Anahi Vasconsuelo, Lucía Pronsato, and A. La Colla

Subjects
medicine.medical_specialty, Histology, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, Skeletal muscle, Endocrinology, medicine.anatomical_structure, Internal medicine, medicine, 17s estradiol, business, C2C12, Testosterone
Published
2015

13. The antiapoptotic effect of 17ß-estradiol in skeletal muscle cells involves PKCδ, JNK and p66Shc

Author

Andrea Anahi Vasconsuelo, R.L. Boland, Lucía Pronsato, A. La Colla, and Lorena Magdalena Milanesi

Subjects
medicine.medical_specialty, Histology, medicine.anatomical_structure, Endocrinology, Physiology, Chemistry, Apoptosis, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Skeletal muscle, 17s estradiol
Abstract

Fil: la Colla, Anabela Belen. Universidad Nacional del Sur. Departamento de Biologia, Bioquimica y Farmacia; Argentina

Published
2016

14. Effect of testosterone on the regulation of protein and gene expression related to oxidative stress damage in C2C12 cells

Author

Lucía Pronsato, Ricardo Boland, Andrea Anahi Vasconsuelo, Lorena Magdalena Milanesi, and A. La Colla

Subjects
021110 strategic, defence & security studies, medicine.medical_specialty, Histology, Physiology, Endocrinology, Diabetes and Metabolism, 0211 other engineering and technologies, Skeletal muscle, 02 engineering and technology, 010501 environmental sciences, Biology, medicine.disease_cause, 01 natural sciences, medicine.anatomical_structure, Endocrinology, Apoptosis, Internal medicine, Gene expression, medicine, C2C12, Testosterone, Oxidative stress, 0105 earth and related environmental sciences
Abstract

Fil: Pronsato, Lucia. Consejo Nacional de Investigaciones Cientificas y Tecnicas; Argentina. Universidad Nacional del Sur. Departamento de Biologia, Bioquimica y Farmacia; Argentina

Published
2016

15. VDR and P38 mapk involvement in 1α,25(OH) 2 -vitamin D3 modulation of myogenesis in skeletal muscle cells

Author

Ricardo Boland, Ana Paula Irazoqui, N. Heim, and Claudia Buitrago

Subjects
Vitamin, medicine.medical_specialty, Histology, Physiology, Myogenesis, Endocrinology, Diabetes and Metabolism, p38 mitogen-activated protein kinases, Skeletal muscle, Calcitriol receptor, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, chemistry, Internal medicine, medicine
Published
2016

20. Anti-apoptotic effects of 17β-estradiol in skeletal muscle cells mediated by the B isoform of estrogen receptor

Author

Ana Carolina Ronda, Lorena Magdalena Milanesi, R.L. Boland, A. Russo de Boland, and Andrea Anahi Vasconsuelo

Subjects
medicine.medical_specialty, Histology, Physiology, Chemistry, Endocrinology, Diabetes and Metabolism, Estrogen receptor, Skeletal muscle, Estrogen-related receptor alpha, Endocrinology, medicine.anatomical_structure, Internal medicine, medicine, Estrogen-related receptor gamma, ITGA7, Estrogen receptor alpha, Estrogen receptor beta, Insulin-like growth factor 1 receptor
Published
2007

21. Parathyroid hormone related peptide (PTHrP) stimulates human colon adenocarcinoma cell proliferation through ERK 1/2, P38 MAPK and PI3K/AKT Pathways

Author

V. Wies Mancini, María Julia Martín, Claudia Gentili, Natalia Calvo, and A. Russo de Boland

Subjects
MAPK/ERK pathway, medicine.medical_specialty, Histology, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, p38 mitogen-activated protein kinases, Inflammation, Osteoarthritis, medicine.disease, Basal (phylogenetics), Endocrinology, Internal medicine, medicine, Synovial fluid, Zymography, medicine.symptom, business, Protein kinase B
Abstract

Introduction: The use of pamidronate in horses with OA could prevent resorptive phenomena associated with joint disease, and may reduce the inflammatory process and resulting pain. Objective was to analyze differences in clinical scores in horses with osteoarthritis before and after the treatment with pamidronate and standardized correlation with the protein profile and inflammatory markers (IL-6, TNF-α, MMP-2 and MMP-9).Materials and methods: Inflammation markers of synovial fluid from clinically healthy horses (clinical score ≤ 4), and patients (n = 5) (clinical score N 5–9) were evaluated basal and days 3, 10 and 21 after treatment. On day 0 and day 2 intravenous pamidronate (90 mg) were applied to the sick horses. IL-6 and TNF-α were assessed by ELISA; MMP-2 and 9 were evaluated by zymography. Changes in synovial fluid protein profile of pre and post treatment were evaluated by SDS-PAGE. Direct BP inhibition on MMP-9 activity in vitro was determined by zymography. Results: IL-6 did not show significant difference, TNF-α; increased at day 21 post treatment, differences were observed between healthy group and “day 3” (p b 0.001) and “untreated patients” (p b 0.01). For MMP-2 p= ns and MMP-9 showed significant individual differences after the second dose And in protein profile study, before and after treatment, no significant differences were observed. Conclusion: Pamidronate reduced MMP-9 activity. Protease was involved in the degenerative and inflammatory processes by degrading the extracellular matrix, but no direct inhibition on MMP-9 occurred. For TNF-α, the increased may be associated with a certain exacerbation of the inflammatory process which can be considered as beneficial to the resolution of chronic arthritis.

Published
2015

26. Parathyroid hormone stimulates the mitogen-activated protein kinase pathway of intestinal cells in rats, a mechanism affected by aging

Author

Ricardo Boland, Claudia Gentili, and A. Russo de Boland

Subjects
medicine.medical_specialty, Histology, biology, Physiology, Mechanism (biology), Chemistry, Endocrinology, Diabetes and Metabolism, Parathyroid hormone, Endocrinology, P70S6 kinase, Internal medicine, Mitogen-activated protein kinase, medicine, biology.protein, ASK1, Calcium-sensing receptor
Published
2001

31. Extracellular ATP activates MAP kinase cascades and increases intestinal Caco-2 cell proliferation

Author

Ricardo Boland, A. Russo de Boland, Natalia Sol Buzzi, and P. Scodelaro Bilbao

Subjects
Histology, biology, MAP kinase kinase kinase, Physiology, Chemistry, Endocrinology, Diabetes and Metabolism, Cyclin-dependent kinase 2, MAPK7, Cyclin-dependent kinase 3, Mitogen-activated protein kinase kinase, Cell biology, biology.protein, Integrin-linked kinase, ASK1, MAPK14
Published
2009

35. Modulation of transcription factors by ATP in breast cancer and osteoblastic cells

Author

Ricardo Boland, Sebastian Katz, A. Russo de Boland, P. Scodelaro Bilbao, and Graciela Santillán

Subjects
Oncology, medicine.medical_specialty, Histology, Breast cancer, Physiology, business.industry, Modulation, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, business, medicine.disease, Transcription factor
Published
2007

36. Non-classical localization of estrogen receptors in C2C12 murine skeletal muscle cell line

Author

Ricardo Boland, Lorena Magdalena Milanesi, and A. Russo de Boland

Subjects
medicine.medical_specialty, Histology, Skeletal muscle cell, Physiology, Chemistry, Endocrinology, Diabetes and Metabolism, Estrogen receptor, Endocrinology, Internal medicine, medicine, Line (text file), ITGA7, C2C12, Estrogen receptor alpha, Estrogen receptor beta
Published
2007

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