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Start Over Author "Ichiro Kawada" Journal bmj open respiratory research
4 results on '"Ichiro Kawada"'

1. Cluster analysis of long COVID in Japan and association of its trajectory of symptoms and quality of life

Author

Yasunori Sato, Katsunori Masaki, Takanori Asakura, Koichi Fukunaga, Naoto Minematsu, Makoto Ishii, Keita Masuzawa, Ichiro Kawada, Tadashi Manabe, Masahiro Kondo, Shotaro Chubachi, Ho Namkoong, Hideki Terai, Junko Kagyo, Tetsuya Shiomi, Keiko Ohgino, Sohei Nakayama, Yusuke Suzuki, Yohei Funatsu, Hidefumi Koh, Ryo Takemura, Fumimaro Ito, Mizuha Hashiguchi, Takahiro Fukui, and Jun Miyata

Subjects
Medicine, Diseases of the respiratory system, RC705-779
Abstract

Background Multiple prolonged symptoms observed in patients who recovered from COVID-19 are defined as long COVID. Although diverse phenotypic combinations are possible, they remain unclear. This study aimed to perform a cluster analysis of long COVID in Japan and clarify the association between its characteristics and background factors and quality of life (QOL).Methods This multicentre prospective cohort study collected various symptoms and QOL after COVID-19 from January 2020 to February 2021. This study included 935 patients aged ≥18 years with COVID-19 at 26 participating medical facilities. Hierarchical cluster analysis was performed using 24 long COVID symptom at 3 months after diagnosis.Results Participants were divided into the following five clusters: numerous symptoms across multiple organs (cluster 1, n=54); no or minor symptoms (cluster 2, n=546); taste and olfactory disorders (cluster 3, n=76); fatigue, psychoneurotic symptoms and dyspnoea (low prevalence of cough and sputum) (cluster 4, n=207) and fatigue and dyspnoea (high prevalence of cough and sputum) (cluster 5, n=52). Cluster 1 included elderly patients with severe symptoms, while cluster 3 included young female with mild symptoms. No significant differences were observed in the comorbidities. Cluster 1 showed the most impaired QOL, followed by clusters 4 and 5; these changes as well as the composition of symptoms were observed over 1 year.Conclusions We identified patients with long COVID with diverse characteristics into five clusters. Future analysis of these different pathologies could result in individualised treatment of long COVID.Trial registration number The study protocol is registered at UMIN clinical trials registry (UMIN000042299).

Published
2024
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2. Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol

Author

Takanori Kanai, Yasunori Sato, Keigo Kobayashi, Katsunori Masaki, Fumitake Saito, Atsushi Kumanogoh, Toru Takebayashi, Yuko Kitagawa, Kazuo Tsubota, Kazuno Negishi, Koichi Fukunaga, Hajime Tabuchi, Masaru Mimura, Naoto Minematsu, Yoshito Takeda, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Keita Masuzawa, Shinnosuke Ikemura, Ichiro Kawada, Tadashi Manabe, Hiroyuki Yasuda, Hiroki Kabata, Eisuke Shimizu, Daisuke Ito, Saeko Takahashi, Shigeto Shimmura, Ho Lee, Takashi Ishiguro, Ryuya Edahiro, Akira Umeda, Toshiro Sato, Rei Goto, Shotaro Chubachi, Naoki Miyazaki, Jin Nakahara, Masaki Okamoto, Yoshitaka Oyamada, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Takae Tanosaki, Kyoko Shimamoto, Hiromu Tanaka, Satoshi Okamori, Yoshiki Ishibashi, Sei Harada, Takanori Fujita, Shogyoku Bun, Sho Kanzaki, Keitaro Fukuda, Jun Yamagami, Toshiyuki Hirano, Takashi Inoue, Junko Kagyo, Tetsuya Shiomi, Keiko Ohgino, Koichi Sayama, Kengo Otsuka, Naoki Miyao, Toshio Odani, Sohei Nakayama, Yusuke Suzuki, Rie Baba, Ichiro Nakachi, Naota Kuwahara, Shuko Mashimo, Soichiro Ueda, Yohei Funatsu, Hidefumi Koh, Takashi Yoshiyama, Kota Ishioka, Morio Nakamura, Ai Goto, Norihiro Harada, Yu Kusaka, Yasushi Nakano, Kazumi Nishio, Hiroki Tateno, Nobuhiro Kodama, Kazuto Hagimura, Ryo Takemura, Kaoru Ogawa, Masayuki Amagai, and Yoko Ibuka

Subjects
Medicine, Diseases of the respiratory system, RC705-779
Published
2021
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3. Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol

Author

Atsushi Kumanogoh, Yuko Kitagawa, Hiroki Tateno, Shinnosuke Ikemura, Yasushi Nakano, Takashi Inoue, Jin Nakahara, Kazuno Negishi, Tadashi Manabe, Naoki Miyao, Junko Kagyo, Kensuke Nakagawara, Naoki Hasegawa, Eisuke Shimizu, Toshiro Sato, Ho Namkoong, Sohei Nakayama, Shogyoku Bun, Fumitake Saito, Kota Ishioka, Keita Masuzawa, Masayuki Amagai, Nobuhiro Kodama, Hiromu Tanaka, Hajime Tabuchi, Rei Goto, Saeko Takahashi, Shuko Mashimo, Kyoko Shimamoto, Makoto Ishii, Shotaro Chubachi, Soichiro Ueda, Sei Harada, Masaki Okamoto, Takashi Ishiguro, Sho Kanzaki, Yu Kusaka, Toshio Odani, Ichiro Nakachi, Koichi Fukunaga, Hidefumi Koh, Toshiyuki Hirano, Naota Kuwahara, Koichi Sayama, Ichiro Kawada, Morio Nakamura, Yohei Funatsu, Kazumi Nishio, Yoshitaka Oyamada, Yoko Ibuka, Masaru Mimura, Yoshiki Ishibashi, Yasunori Sato, Ho Lee, Naoki Miyazaki, Yusuke Suzuki, Takae Tanosaki, Ryo Takemura, Rie Baba, Takanori Kanai, Kazuto Hagimura, Ai Goto, Toru Takebayashi, Daisuke Ito, Naoto Minematsu, Takashi Yoshiyama, Hideki Terai, Satoshi Okamori, Tetsuya Shiomi, Keiko Ohgino, Takanori Fujita, Norihiro Harada, Shigeto Shimmura, Akira Umeda, Jun Yamagami, Kengo Otsuka, Yoshito Takeda, Katsunori Masaki, Hirofumi Kamata, Kazuo Tsubota, Hiroki Kabata, Kaoru Ogawa, Keigo Kobayashi, Hiroyuki Yasuda, Ryuya Edahiro, and Keitaro Fukuda

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Respiratory Infection, Disease, Cohort Studies, Diseases of the respiratory system, Japan, Quality of life, medicine, Clinical endpoint, Humans, Multicenter Studies as Topic, Social determinants of health, Socioeconomic status, RC705-779, SARS-CoV-2, business.industry, COVID-19, Respiratory infection, clinical epidemiology, Family medicine, Scale (social sciences), Disease Progression, Quality of Life, Medicine, business, Cohort study
Abstract

IntroductionThe rapid spread of COVID-19 posed a global burden. Substantial number of people died of the disease in the acute phase of infection. In addition, a significant proportion of patients have been reported to suffer from post-acute phase symptoms, sequelae of COVID-19, which may negatively influence the quality of daily living and/or socioeconomic circumstances of the patients. However, no previous study has comprehensively and objectively assessed the quality of life of patients by using existing international scales. Further, evidence of socioeconomic consequences among patients with COVID-19 is scarce. To address the multidimensional issues from sequelae of COVID-19, evidence from comprehensive surveys beyond clinical perspectives is critical that investigates health, and social determinants of disease progression as well as socioeconomic consequences at a large scale.Methods and analysisIn this study, we plan to conduct a nationwide and comprehensive survey for the sequelae of COVID-19 in a total of 1000 patients diagnosed at 27 hospitals throughout Japan. This study will evaluate not only the health-related status of patients from clinical perspectives but also the Health-related Quality of Life (HRQoL) scores, socioeconomic status and consequences to discuss the sequelae of the disease and the related risk factors. The primary endpoint is the frequency of long-term complications of COVID-19 infection. The secondary endpoints are risk factors for progression to sequelae of COVID-19 infection. The study will provide robust and important evidence as a resource to tackle the issues from the sequelae of COVID-19 from the multi-dimensional perspectives.Ethics and disseminationThis trial was approved by the Keio University School of Medicine Ethics Committee (20200243, UMIN000042299). The results of this study will be reported at a society meeting or published in a peer-reviewed journal.

Published
2021

4. Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol.

Author

Ho Namkoong, Kensuke Nakagawara, Hideki Terai, Katsunori Masaki, Takae Tanosaki, Kyoko Shimamoto, Ho Lee, Hiromu Tanaka, Satoshi Okamori, Hiroki Kabata, Shotaro Chubachi, Shinnosuke Ikemura, Hirofumi Kamata, Hiroyuki Yasuda, Ichiro Kawada, Makoto Ishii, Yoshiki Ishibashi, Sei Harada, Takanori Fujita, Daisuke Ito, and Shogyoku Bun

Published
2021
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