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1. Establishing a case definition of thiamine responsive disorders among infants and young children in Lao PDR: protocol for a prospective cohort study.

Author

Hess, Sonja Y, Smith, Taryn J, Fischer, Philip R, Trehan, Indi, Hiffler, Laurent, Arnold, Charles D, Sitthideth, Dalaphone, Tancredi, Daniel J, Schick, Michael A, Yeh, Jay, Stein-Wexler, Rebecca, McBeth, Christine N, Tan, Xiuping, Nhiacha, Kouyang, and Kounnavong, Sengchanh

Subjects
Humans, Thiamine Deficiency, Thiamine, Risk Factors, Prospective Studies, Research Design, Infant, Infant, Newborn, Laos, Female, Observational Studies as Topic, echocardiography, neuroradiology, nutrition & dietetics, paediatrics, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

IntroductionDiagnosis of infantile thiamine deficiency disorders (TDD) is challenging due to the non-specific, highly variable clinical presentation, often leading to misdiagnosis. Our primary objective is to develop a case definition for thiamine responsive disorders (TRD) to determine among hospitalised infants and young children, which clinical features and risk factors identify those who respond positively to thiamine administration.Methods and analysisThis prospective study will enrol 662 children (aged 21 days to

Published
2020

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