Search

Your search keyword '"Hirofumi Nishio"' showing total 2 results
Start Over Author "Hirofumi Nishio" Journal bmj open
2 results on '"Hirofumi Nishio"'

1. Study protocol for a randomised placebo controlled trial of platelet-rich plasma injection to prevent post-traumatic knee osteoarthritis after anterior cruciate ligament reconstruction

Author

Masashi Nagao, Yoshitomo Saita, Muneaki Ishijima, Yohei Kobayashi, Keiji Kobayashi, Haruka Kaneko, Hirofumi Nishio, Yasumasa Momoi, Ryosuke Nakajima, Sayuri Uchino, Takanori Wakayama, Shin Fukusato, Suguru Wakana, Jun Tomura, Keiichi Yoshida, and Mitsuaki Kubota

Subjects
Medicine
Abstract

Introduction The elevated cytokine levels in patients suffering from anterior cruciate ligament (ACL) rupture may lead to acute post-traumatic arthritis (APTA) and post-traumatic osteoarthritis (PTOA). Due to its chondrogenerative and anti-inflammatory effect, platelet-rich plasma (PRP) therapy is expected to show a positive outcome in APTA and PTOA. The proposed trial aims to quantitatively measure the efficacy of PRP injection in arresting post-traumatic cartilage degeneration among patients after ACL reconstruction.Methods and analysis This will be a single-blind, randomised, prospective, controlled clinical trial designed following the Consolidated Standards of Reporting Trials guidelines. After ACL reconstruction, 80 patients will be randomised to receive either leucocyte-poor PRP injection after joint aspiration or a placebo control group receiving only joint aspiration. Participants (age 20–49 years) will be those who have undergone ACL reconstruction within the past 2 weeks with a body mass index

Published
2022
Full Text
View/download PDF

2. Study protocol for a randomised placebo controlled trial of platelet-rich plasma injection to prevent post-traumatic knee osteoarthritis after anterior cruciate ligament reconstruction

Author

Yasumasa Momoi, Yoshitomo Saita, Masashi Nagao, Yohei Kobayashi, Ryosuke Nakajima, Sayuri Uchino, Takanori Wakayama, Hirofumi Nishio, Shin Fukusato, Suguru Wakana, Jun Tomura, Keiji Kobayashi, Keiichi Yoshida, Haruka Kaneko, Mitsuaki Kubota, and Muneaki Ishijima

Subjects
Adult, Young Adult, Anterior Cruciate Ligament Reconstruction, Platelet-Rich Plasma, Anterior Cruciate Ligament Injuries, Humans, Single-Blind Method, Prospective Studies, General Medicine, Middle Aged, Osteoarthritis, Knee, Randomized Controlled Trials as Topic
Abstract

IntroductionThe elevated cytokine levels in patients suffering from anterior cruciate ligament (ACL) rupture may lead to acute post-traumatic arthritis (APTA) and post-traumatic osteoarthritis (PTOA). Due to its chondrogenerative and anti-inflammatory effect, platelet-rich plasma (PRP) therapy is expected to show a positive outcome in APTA and PTOA. The proposed trial aims to quantitatively measure the efficacy of PRP injection in arresting post-traumatic cartilage degeneration among patients after ACL reconstruction.Methods and analysisThis will be a single-blind, randomised, prospective, controlled clinical trial designed following the Consolidated Standards of Reporting Trials guidelines. After ACL reconstruction, 80 patients will be randomised to receive either leucocyte-poor PRP injection after joint aspiration or a placebo control group receiving only joint aspiration. Participants (age 20–49 years) will be those who have undergone ACL reconstruction within the past 2 weeks with a body mass indexEthics and disseminationThe study was approved by The Independent Ethics Committee for Clinical Trials of the Japanese Association for the Promotion of State-of-the-Art Medicine. Results of the trial and each of the outcomes will be shared via conferences and publication in a peer-reviewed journal.Trial registration numberjRCTb030200391.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results