1. Brazilian network of COVID-19 during pregnancy (REBRACO: a multicentre study protocol)
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Elias F Melo Júnior, Renato T Souza, José Guilherme Cecatti, Renato Passini Jr, Jussara Mayrink, Maria Laura Costa, Debora F Leite, Janete Vettorazzi, Ricardo P Tedesco, Fernanda G Surita, Rodolfo C Pacagnella, Carla B Andreucci, Marcos Nakamura-Pereira, Marcos Augusto Bastos Dias, Luis Bahamondes, Maria J Miele, Karayna G Fernandes, Silvana F Bento, Carolina C Ribeiro-do-Valle, Adriana G Luz, Giuliane J Lajos, Silvia B Mazon, Guilherme M Nobrega, Thayna B Griggio, Charles M'poca Charles, Sergio Martins-Costa, Frederico JA Peret, Francisco E Feitosa, Rosiane Mattar, Evelyn Traina, Edson V Cunha Filho, Samira M Haddad, José Paulo Guida, Mario D Correa Junior, Leandro G Oliveira, Carlos AS Menezes, Marília GQ Luz, Sherly Metelus, Lester Castro, Stephanie Pabon, Rachel Soeiro, Amanda D Silva, Paulo S R Junior, Thais G Sardinha, Rodolfo R Japenga, Erica R F Urquiza, Maíra R Machado, Marcela Maria Simões, Larissa M Solda, Sue Yazaki-Sun, Priscilla Mota, Arimaza C Soares, Ellen Machado, Anne Bergmann, Gustavo Raupp dos Santos, Patrícia B Peres, Cristiane L Arbeli, Rafael M Quevedo, Carolina F Yamashita, Julia D Corradin, Isabella Bergamini, José Geraldo L Ramos, Maria Lúcia R Oppermann, Laisa S Quadro, Lina Marins, Érika V Paniz, Thaís Vicentini Xavier, Bruna E Parreira, Aline Tosetto, Sabrina Savazoni, Aline C Costa, Marina HL Almeida, Bruna FV Moura, Lidiane R França, Hanna Vieira, Rafael B Aquino, Isabella Monteiro, Bruna O Guerra, Gabriela Gorga, Daisy Pinheiro, Denise Cordeiro, Priscila L Miná, Carol Dornellas, Kevin FA Oliveira, Caio Leal, Rayra Amana, Cristiane O Santos, Marina M dos Santos, Carlos Neto, Thiago Gomes, Isabela R Pereira, Clélia Andrade Salustrino, Valéria B Pontes, Roberto Allen da Silva Franco, João Paolo Bilibio, Gislânia PF Brito, Hana Paula C Pinto, Danielle Leal de Oliveira, Andrezza A Guerra, Andrea O Moura, Natasha Pantoja, Fernanda David, Alina Silva, Juliana Vasconcellos Freitas-Jesus, Angela M Bacha, Anderson Borovac-Pinheiro, Belmiro G Pereira, Eliana M Amaral, Elton Carlos Ferreira, Helaine MBPM Milanez, Jamil P S Caldas, Luiz F Baccaro, Marcelo L Nomura, Patrícia M Rehder, Renata Z Simone, Cristiano Torrezan, Jose L P Modena, Magnun N Nunes dos Santos, Sergio T M Marba, Tabata Z Dias, and Mariana EV
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Medicine - Abstract
Introduction The aim of this study was to evaluate the clinical, epidemiological and laboratory aspects of SARS-CoV-2 infection during pregnancy and postpartum in 16 maternity hospitals.Methods and analysis A prospective multicentre study, with five axes. First, the prevalence of SARS-CoV-2 infection among women admitted for childbirth will be described in a cross-sectional study. Second, maternal and perinatal outcomes will be assessed in a prospective cohort study including pregnant or postpartum women with suspected COVID-19. Third, a cohort of positive COVID-19 cases with sampling of a variety of biological material. Histopathological and viral analysis of biological maternal and neonatal samples will be performed, and the assessment of nutritional variables to evaluate the association between vitamin D and severity of infection. Fourth, a monitoring and evaluation committee to collect relevant healthcare information and plan actions in centres facing the pandemic. Furthermore, qualitative studies will be performed to study pregnant women, their families and health professionals. Fifth, an ecological study will monitor the number of live births, stillbirths and other outcomes to explore any trend among the periods before, during and after the pandemic. Data will systematically be collected in an electronic platform following standardised operational procedures. For quantitative study components, an appropriate statistical approach will be used for each analysis. For qualitative data, in-depth interviews recorded in audio will be transcribed, checking the text obtained with the recording. Subsequently, thematic analysis with the aid of the NVivo programme will be performed.Ethics and dissemination Ethical approval was obtained (letters of approval numbers 4.047.168, 4.179.679 and 4.083.988). All women will be fully informed to sign the consent form before enrolment in the study. Findings will be disseminated through peer-reviewed journals and scientific conferences.
- Published
- 2021
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